FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2744951109> ?p ?o ?g. }

• W2744951109 endingPage "5033" @default.
• W2744951109 startingPage "5027" @default.
• W2744951109 abstract "Ginkgetin is a natural biflavonoid isolated from the leaves of Ginkgo biloba, and is characterized by its anti-inflammatory and anti-viral activities. Although numerous studies state that it has also antitumor activity, the anti-proliferative effect of ginkgetin and the underlying mechanism in breast cancer cells have not yet been investigated. In the present study, ginkgetin inhibited the cell viability of MCF-7 and T-47D cells dose-dependently, and suppressed the expression of the estrogen receptor (ER) at the mRNA and protein levels. Among the targets of the ER, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), cyclin D1 and survivin were also downregulated by ginkgetin treatment. The anti-proliferative effects of ginkgetin were sufficient to suppress the growth by estradiol stimulation. However, ginkgetin did not significantly affect the viability of MDA-MB-231 cells, which are ER-negative cells. Furthermore, the knockdown of the ER and an inhibitor of PFKFB3 significantly sensitized MCF-7 and T-47D cells to ginkgetin. These findings suggest that ginkgetin induces cell death in ER-positive breast cancer cells via the inhibition of ER expression and that it is a promising agent for breast cancer treatment." @default.
• W2744951109 created "2017-08-17" @default.
• W2744951109 creator A5004271758 @default.
• W2744951109 creator A5005999525 @default.
• W2744951109 creator A5013544822 @default.
• W2744951109 creator A5037531553 @default.
• W2744951109 creator A5051252759 @default.
• W2744951109 creator A5058891568 @default.
• W2744951109 creator A5059886217 @default.
• W2744951109 creator A5065785561 @default.
• W2744951109 creator A5085690999 @default.
• W2744951109 creator A5087591024 @default.
• W2744951109 date "2017-08-10" @default.
• W2744951109 modified "2023-10-18" @default.
• W2744951109 title "Ginkgetin induces cell death in breast cancer cells via downregulation of the estrogen receptor" @default.
• W2744951109 cites W11697548 @default.
• W2744951109 cites W1906888631 @default.
• W2744951109 cites W1927418190 @default.
• W2744951109 cites W1981016944 @default.
• W2744951109 cites W1988497096 @default.
• W2744951109 cites W1996087074 @default.
• W2744951109 cites W2027379193 @default.
• W2744951109 cites W2030678473 @default.
• W2744951109 cites W2030700564 @default.
• W2744951109 cites W2040076618 @default.
• W2744951109 cites W2047123960 @default.
• W2744951109 cites W2051869030 @default.
• W2744951109 cites W2064945155 @default.
• W2744951109 cites W2103372520 @default.
• W2744951109 cites W2107277218 @default.
• W2744951109 cites W2121071871 @default.
• W2744951109 cites W2128635872 @default.
• W2744951109 cites W2146984617 @default.
• W2744951109 cites W2166027333 @default.
• W2744951109 cites W2192080449 @default.
• W2744951109 cites W2531506996 @default.
• W2744951109 cites W340664217 @default.
• W2744951109 cites W4248595930 @default.
• W2744951109 cites W4293247451 @default.
• W2744951109 doi "https://doi.org/10.3892/ol.2017.6742" @default.
• W2744951109 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5649541" @default.
• W2744951109 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29085516" @default.
• W2744951109 hasPublicationYear "2017" @default.
• W2744951109 type Work @default.
• W2744951109 sameAs 2744951109 @default.
• W2744951109 citedByCount "19" @default.
• W2744951109 countsByYear W27449511092019 @default.
• W2744951109 countsByYear W27449511092020 @default.
• W2744951109 countsByYear W27449511092021 @default.
• W2744951109 countsByYear W27449511092022 @default.
• W2744951109 countsByYear W27449511092023 @default.
• W2744951109 crossrefType "journal-article" @default.
• W2744951109 hasAuthorship W2744951109A5004271758 @default.
• W2744951109 hasAuthorship W2744951109A5005999525 @default.
• W2744951109 hasAuthorship W2744951109A5013544822 @default.
• W2744951109 hasAuthorship W2744951109A5037531553 @default.
• W2744951109 hasAuthorship W2744951109A5051252759 @default.
• W2744951109 hasAuthorship W2744951109A5058891568 @default.
• W2744951109 hasAuthorship W2744951109A5059886217 @default.
• W2744951109 hasAuthorship W2744951109A5065785561 @default.
• W2744951109 hasAuthorship W2744951109A5085690999 @default.
• W2744951109 hasAuthorship W2744951109A5087591024 @default.
• W2744951109 hasBestOaLocation W27449511091 @default.
• W2744951109 hasConcept C104317684 @default.
• W2744951109 hasConcept C121608353 @default.
• W2744951109 hasConcept C127561419 @default.
• W2744951109 hasConcept C172313692 @default.
• W2744951109 hasConcept C173396325 @default.
• W2744951109 hasConcept C190283241 @default.
• W2744951109 hasConcept C199835354 @default.
• W2744951109 hasConcept C2775975398 @default.
• W2744951109 hasConcept C29537977 @default.
• W2744951109 hasConcept C502942594 @default.
• W2744951109 hasConcept C530470458 @default.
• W2744951109 hasConcept C53227056 @default.
• W2744951109 hasConcept C54355233 @default.
• W2744951109 hasConcept C55493867 @default.
• W2744951109 hasConcept C62112901 @default.
• W2744951109 hasConcept C84606932 @default.
• W2744951109 hasConcept C86803240 @default.
• W2744951109 hasConcept C96232424 @default.
• W2744951109 hasConceptScore W2744951109C104317684 @default.
• W2744951109 hasConceptScore W2744951109C121608353 @default.
• W2744951109 hasConceptScore W2744951109C127561419 @default.
• W2744951109 hasConceptScore W2744951109C172313692 @default.
• W2744951109 hasConceptScore W2744951109C173396325 @default.
• W2744951109 hasConceptScore W2744951109C190283241 @default.
• W2744951109 hasConceptScore W2744951109C199835354 @default.
• W2744951109 hasConceptScore W2744951109C2775975398 @default.
• W2744951109 hasConceptScore W2744951109C29537977 @default.
• W2744951109 hasConceptScore W2744951109C502942594 @default.
• W2744951109 hasConceptScore W2744951109C530470458 @default.
• W2744951109 hasConceptScore W2744951109C53227056 @default.
• W2744951109 hasConceptScore W2744951109C54355233 @default.
• W2744951109 hasConceptScore W2744951109C55493867 @default.
• W2744951109 hasConceptScore W2744951109C62112901 @default.
• W2744951109 hasConceptScore W2744951109C84606932 @default.
• W2744951109 hasConceptScore W2744951109C86803240 @default.

• next