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• W2744960472 abstract "Background Induced premature menopause and cardio-toxic therapy increase cardiovascular disease risk in female cancer survivors. Objective To compare the effects of a 12 month aerobic-resistance fitness center intervention to home based physical activity on cardiovascular function and metabolic risk factors. Methods Subjects (N = 154) who had completed primary and/or adjuvant chemotherapy (past 3 years) were randomized to a fitness center intervention or a home based group. The fitness center intervention was a structured thrice weekly aerobic (30 min brisk walking treadmill in target heart range) combined with resistance (30 min of lower body strength training) exercise program, supervised for the first 6 months. The home based group received national guidelines for 30 min moderate intensity exercise most days of the week. Fasting serum samples were collected at baseline, 6 and 12 months for insulin, glucose, lipids and hemoglobin A-1C. A graded exercise stress test was also performed at baseline and 6 months. Results The majority of subjects were white (85.7%), had breast cancer (83.1%) and the average age was 51.9 years. Subjects in the fitness center intervention had significantly improved time on treadmill (p = .039), improved heart rate recovery at 1 min (p = .028), greater MET minutes/week (p ≤ .0001), a trend for improved insulin resistance (p = .067) and stable insulin levels (p = .045) compared to the home based physical activity group. Conclusions Exercise represents a potential cardiac risk reduction intervention for cancer survivors. Clinical Trials.gov NCT01102985." @default.
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• W2744960472 date "2017-09-01" @default.
• W2744960472 modified "2023-09-29" @default.
• W2744960472 title "The Yale Fitness Intervention Trial in female cancer survivors: Cardiovascular and physiological outcomes" @default.
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• W2744960472 doi "https://doi.org/10.1016/j.hrtlng.2017.06.001" @default.
• W2744960472 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6129386" @default.
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