FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2744977013> ?p ?o ?g. }

• W2744977013 abstract "Williams syndrome (WS) is a unique neurodevelopmental disorder with a specific behavioral and cognitive profile, which includes hyperaffiliative behavior, poor social judgment, and lack of social inhibition. Here we examined the morphology of basal dendrites on pyramidal neurons in the cortex of two rare adult subjects with WS. Specifically, we examined two areas in the prefrontal cortex (PFC) – the frontal pole (Brodmann area 10) and the orbitofrontal cortex (Brodmann area 11) – and three areas in the motor, sensory, and visual cortex (BA4, BA3-2-1, BA18). The findings suggest that the morphology of basal dendrites on the pyramidal neurons is altered in the cortex of WS, with differences that were layer-specific, more prominent in PFC areas, and displayed an overall pattern of dendritic organization that differentiates WS from other disorders. In particular, and unlike what was expected based on typically developing brains, basal dendrites in the two PFC areas did not display longer and more branched dendrites compared to motor, sensory and visual areas. Moreover, dendritic branching, dendritic length, and the number of dendritic spines differed little within PFC and between the central executive region (BA 10) and BA 11 that is part of the orbitofrontal region involved into emotional processing. In contrast, the relationship between the degree of neuronal branching in supra- versus infra-granular layers was spared in WS. Although this study utilized tissue held in formalin for a prolonged period of time and the number of neurons available for analysis was limited, our findings indicate that WS cortex, similar to that in other neurodevelopmental disorders such as Down syndrome, Rett syndrome, Fragile X, and idiopathic autism, has altered morphology of basal dendrites on pyramidal neurons, which appears more prominent in selected areas of the PFC. Results were examined from developmental perspectives and discussed in the context of other neurodevelopmental disorders. We have proposed hypotheses for further investigations of morphological changes on basal dendrites in WS, a syndrome of particular interest given its unique social and cognitive phenotype." @default.
• W2744977013 created "2017-08-17" @default.
• W2744977013 creator A5002007717 @default.
• W2744977013 creator A5008544264 @default.
• W2744977013 creator A5035203676 @default.
• W2744977013 creator A5044776329 @default.
• W2744977013 creator A5048789958 @default.
• W2744977013 creator A5067885973 @default.
• W2744977013 creator A5073522117 @default.
• W2744977013 date "2017-08-11" @default.
• W2744977013 modified "2023-10-18" @default.
• W2744977013 title "Basal Dendritic Morphology of Cortical Pyramidal Neurons in Williams Syndrome: Prefrontal Cortex and Beyond" @default.
• W2744977013 cites W1571301764 @default.
• W2744977013 cites W1599549671 @default.
• W2744977013 cites W1965365550 @default.
• W2744977013 cites W1967024413 @default.
• W2744977013 cites W1973875070 @default.
• W2744977013 cites W1975317900 @default.
• W2744977013 cites W1978611788 @default.
• W2744977013 cites W1981765772 @default.
• W2744977013 cites W1991472942 @default.
• W2744977013 cites W2012203722 @default.
• W2744977013 cites W2017773492 @default.
• W2744977013 cites W2020789214 @default.
• W2744977013 cites W2031100775 @default.
• W2744977013 cites W2040268226 @default.
• W2744977013 cites W2044271964 @default.
• W2744977013 cites W2049255471 @default.
• W2744977013 cites W2052422346 @default.
• W2744977013 cites W2052698809 @default.
• W2744977013 cites W2060526931 @default.
• W2744977013 cites W2071466475 @default.
• W2744977013 cites W2071724105 @default.
• W2744977013 cites W2074754346 @default.
• W2744977013 cites W2075606380 @default.
• W2744977013 cites W2075779454 @default.
• W2744977013 cites W2082428573 @default.
• W2744977013 cites W2084189919 @default.
• W2744977013 cites W2086129169 @default.
• W2744977013 cites W2090118472 @default.
• W2744977013 cites W2090490936 @default.
• W2744977013 cites W2091612053 @default.
• W2744977013 cites W2094196257 @default.
• W2744977013 cites W2097106481 @default.
• W2744977013 cites W2098391962 @default.
• W2744977013 cites W2099540856 @default.
• W2744977013 cites W2105416775 @default.
• W2744977013 cites W2105507567 @default.
• W2744977013 cites W2110016065 @default.
• W2744977013 cites W2111843739 @default.
• W2744977013 cites W2114452843 @default.
• W2744977013 cites W2128907707 @default.
• W2744977013 cites W2133613191 @default.
• W2744977013 cites W2137395087 @default.
• W2744977013 cites W2140089219 @default.
• W2744977013 cites W2143473358 @default.
• W2744977013 cites W2144620740 @default.
• W2744977013 cites W2146264275 @default.
• W2744977013 cites W2148386452 @default.
• W2744977013 cites W2150860634 @default.
• W2744977013 cites W2152924070 @default.
• W2744977013 cites W2156205410 @default.
• W2744977013 cites W2158752543 @default.
• W2744977013 cites W2162500823 @default.
• W2744977013 cites W2163122493 @default.
• W2744977013 cites W2165137514 @default.
• W2744977013 cites W2168596204 @default.
• W2744977013 cites W2510152931 @default.
• W2744977013 cites W2513300565 @default.
• W2744977013 cites W4240325318 @default.
• W2744977013 cites W951476706 @default.
• W2744977013 doi "https://doi.org/10.3389/fnins.2017.00419" @default.
• W2744977013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5554499" @default.
• W2744977013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28848376" @default.
• W2744977013 hasPublicationYear "2017" @default.
• W2744977013 type Work @default.
• W2744977013 sameAs 2744977013 @default.
• W2744977013 citedByCount "19" @default.
• W2744977013 countsByYear W27449770132017 @default.
• W2744977013 countsByYear W27449770132018 @default.
• W2744977013 countsByYear W27449770132019 @default.
• W2744977013 countsByYear W27449770132020 @default.
• W2744977013 countsByYear W27449770132021 @default.
• W2744977013 countsByYear W27449770132022 @default.
• W2744977013 countsByYear W27449770132023 @default.
• W2744977013 crossrefType "journal-article" @default.
• W2744977013 hasAuthorship W2744977013A5002007717 @default.
• W2744977013 hasAuthorship W2744977013A5008544264 @default.
• W2744977013 hasAuthorship W2744977013A5035203676 @default.
• W2744977013 hasAuthorship W2744977013A5044776329 @default.
• W2744977013 hasAuthorship W2744977013A5048789958 @default.
• W2744977013 hasAuthorship W2744977013A5067885973 @default.
• W2744977013 hasAuthorship W2744977013A5073522117 @default.
• W2744977013 hasBestOaLocation W27449770131 @default.
• W2744977013 hasConcept C105702510 @default.
• W2744977013 hasConcept C148762608 @default.
• W2744977013 hasConcept C15744967 @default.
• W2744977013 hasConcept C169760540 @default.
• W2744977013 hasConcept C169900460 @default.
• W2744977013 hasConcept C174884520 @default.

• next