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• W2745051181 abstract "Abstract Placement of an initiator aminoacyl-tRNA [(f)Met-tRNA i (f)Met ] base paired with the AUG initiation codon of a messenger RNA (mRNA) is the first step of translation. The eukaryotic translation factor eIF5B or its bacerial homologue IF2 facilitate the correct positioning of initiator tRNA in the P site of the ribosome. We report the electron cryomicroscopy (cryoEM) structure of a stabilized intermediate state of a yeast 80S/tRNAi Met /eIF5B complex at 3.6 Å resolution. The structure shows how a universally conserved tyrosine couples the rotational state of the small ribosomal subunit with GTP hydrolysis." @default.
• W2745051181 created "2017-08-17" @default.
• W2745051181 creator A5073767436 @default.
• W2745051181 creator A5086176987 @default.
• W2745051181 date "2017-08-04" @default.
• W2745051181 modified "2023-09-24" @default.
• W2745051181 title "GTP Hydrolysis by eIF5B in the Last Step of Translation Initiation Is Activated by a Rotation of the Small Ribosomal Subunit" @default.
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• W2745051181 doi "https://doi.org/10.1101/172825" @default.
• W2745051181 hasPublicationYear "2017" @default.
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