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- W2745154832 abstract "The T-cell-dependent antibody response (TDAR) is a functional assay widely utilized in the chemical and pharmaceutical industries to assess the ability of a test system to mount an antibody response (IgM and/or IgG) against a T-cell-dependent antigen. Specifically, the assay measures the outcome of an immunization that is dependent upon the effectiveness of multiple immune processes including antigen uptake and presentation, T-cell help, B-cell activation, and antibody production. In designing and/or incorporating a TDAR assay into a repeat-dose toxicology study, specific factors and endpoints need to be considered which include antigen selection, animal species, strain, gender, number, origin, timing of immunization and route/dose of antigen, sampling schedule, analytical method, and data interpretation and statistics. In addition, regulatory guidelines have been established by several agencies to provide guidance and harmonization on the conduct and utilization of the TDAR assay." @default.
- W2745154832 created "2017-08-17" @default.
- W2745154832 creator A5002745217 @default.
- W2745154832 creator A5058116120 @default.
- W2745154832 creator A5083438463 @default.
- W2745154832 date "2018-01-01" @default.
- W2745154832 modified "2023-10-12" @default.
- W2745154832 title "T-Cell-Dependent Antibody Response Assay: Biology, Methods, and Application" @default.
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