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- W2745248735 abstract "Discovery of Piezo channels and the reporting of their sensitivity to the inhibitor GsMTx4 were important milestones in the study of non-selective cationic mechanosensitive channels (MSCs) in normal physiology and pathogenesis. GsMTx4 had been used for years to investigate the functional role of cationic MSCs, especially in muscle tissue, but with little understanding of its target or inhibitory mechanism. The sensitivity of Piezo channels to bilayer stress and its robust mechanosensitivity when expressed in heterologous systems were keys to determining GsMTx4's mechanism of action. However, questions remain regarding Piezo's role in muscle function due to the non-selective nature of GsMTx4 inhibition toward membrane mechanoenzymes and the implication of MCS channel types by genetic knockdown. Evidence supporting Piezo like activity, at least in the developmental stages of muscle, is presented. While the MSC targets of GsMTx4 in muscle pathology are unclear, its muscle protective effects are clearly demonstrated in two recent in situ studies on normal cardiomyocytes and dystrophic skeletal muscle. The muscle protective function may be due to the combined effect of GsMTx4's inhibitory action on cationic MSCs like Piezo and TRP, and its potentiation of repolarizing K+ selective MSCs like K2P and SAKCa. Paradoxically, the potent in vitro action of GsMTx4 on many physiological functions seems to conflict with its lack of in situ side-effects on normal animal physiology. Future investigations into cytoskeletal control of sarcolemma mechanics and the suspected inclusion of MSCs in membrane micro/nano sized domains with distinct mechanical properties will aide our understanding of this dichotomy." @default.
- W2745248735 created "2017-08-17" @default.
- W2745248735 creator A5054949255 @default.
- W2745248735 date "2017-11-01" @default.
- W2745248735 modified "2023-10-16" @default.
- W2745248735 title "Piezo channels and GsMTx4: Two milestones in our understanding of excitatory mechanosensitive channels and their role in pathology" @default.
- W2745248735 cites W108909600 @default.
- W2745248735 cites W1550219250 @default.
- W2745248735 cites W1594958231 @default.
- W2745248735 cites W1597709568 @default.
- W2745248735 cites W1608105537 @default.
- W2745248735 cites W1813097575 @default.
- W2745248735 cites W1918744139 @default.
- W2745248735 cites W1928745964 @default.
- W2745248735 cites W1962824001 @default.
- W2745248735 cites W1964352365 @default.
- W2745248735 cites W1970414934 @default.
- W2745248735 cites W1970848490 @default.
- W2745248735 cites W1972071814 @default.
- W2745248735 cites W1973988298 @default.
- W2745248735 cites W1974683581 @default.
- W2745248735 cites W1974938825 @default.
- W2745248735 cites W1975712774 @default.
- W2745248735 cites W1975854407 @default.
- W2745248735 cites W1977731744 @default.
- W2745248735 cites W1979324842 @default.
- W2745248735 cites W1980113670 @default.
- W2745248735 cites W1982282409 @default.
- W2745248735 cites W1984533345 @default.
- W2745248735 cites W1984602413 @default.
- W2745248735 cites W1987900026 @default.
- W2745248735 cites W1988378570 @default.
- W2745248735 cites W1990859310 @default.
- W2745248735 cites W1992126189 @default.
- W2745248735 cites W1993997908 @default.
- W2745248735 cites W1994285472 @default.
- W2745248735 cites W1997700356 @default.
- W2745248735 cites W1997767315 @default.
- W2745248735 cites W1999720993 @default.
- W2745248735 cites W2002246451 @default.
- W2745248735 cites W2006540966 @default.
- W2745248735 cites W2006631825 @default.
- W2745248735 cites W2007184099 @default.
- W2745248735 cites W2010702272 @default.
- W2745248735 cites W2010717774 @default.
- W2745248735 cites W2014287269 @default.
- W2745248735 cites W2016555254 @default.
- W2745248735 cites W2017428989 @default.
- W2745248735 cites W2019129862 @default.
- W2745248735 cites W2020149988 @default.
- W2745248735 cites W2022183837 @default.
- W2745248735 cites W2022538678 @default.
- W2745248735 cites W2024012749 @default.
- W2745248735 cites W2026201281 @default.
- W2745248735 cites W2030806675 @default.
- W2745248735 cites W2033539217 @default.
- W2745248735 cites W2033571894 @default.
- W2745248735 cites W2033933378 @default.
- W2745248735 cites W2035330601 @default.
- W2745248735 cites W2036145275 @default.
- W2745248735 cites W2037864200 @default.
- W2745248735 cites W2038538957 @default.
- W2745248735 cites W2039931031 @default.
- W2745248735 cites W2041345208 @default.
- W2745248735 cites W2045733238 @default.
- W2745248735 cites W2046306077 @default.
- W2745248735 cites W2048814604 @default.
- W2745248735 cites W2050575405 @default.
- W2745248735 cites W2050677481 @default.
- W2745248735 cites W205212658 @default.
- W2745248735 cites W2053090542 @default.
- W2745248735 cites W2057185402 @default.
- W2745248735 cites W2060594376 @default.
- W2745248735 cites W2062279581 @default.
- W2745248735 cites W2062912208 @default.
- W2745248735 cites W2066120734 @default.
- W2745248735 cites W2067581129 @default.
- W2745248735 cites W2076689525 @default.
- W2745248735 cites W2077950886 @default.
- W2745248735 cites W2079062478 @default.
- W2745248735 cites W2080753369 @default.
- W2745248735 cites W2081344083 @default.
- W2745248735 cites W2085805107 @default.
- W2745248735 cites W2087967361 @default.
- W2745248735 cites W2096134550 @default.
- W2745248735 cites W2103915080 @default.
- W2745248735 cites W2106765734 @default.
- W2745248735 cites W2107375830 @default.
- W2745248735 cites W2107634021 @default.
- W2745248735 cites W2109845530 @default.
- W2745248735 cites W2112956889 @default.
- W2745248735 cites W2116294708 @default.
- W2745248735 cites W2118259027 @default.
- W2745248735 cites W2120806902 @default.
- W2745248735 cites W2125942201 @default.
- W2745248735 cites W2126682267 @default.
- W2745248735 cites W2129861564 @default.
- W2745248735 cites W2134577432 @default.