FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2745324069> ?p ?o ?g. }

• W2745324069 endingPage "164" @default.
• W2745324069 startingPage "160" @default.
• W2745324069 abstract "Parkinson's disease (PD) is a neurodegenerative disorder characterized by remarkable phenotypic variability. Accumulated evidence points that the manifestation of PD clinical signs might be differentially modified by genetic factors, as mutations in LRRK2 and GBA genes. In this sense, the clarification of the genotype-phenotype correlations in PD has important implications in predicting prognosis and can contribute to the development of specific therapeutic approaches.Here, we conducted the first comparative analysis of motor and non-motor features in 17 LRRK2 and 22 GBA mutation carriers and 93 non-carriers unrelated PD patients from Brazil, a highly admixed population.Significant differences were found between the three groups. LRRK2 PD patients presented more occurrence of familiar history. Resting tremor was observed in a lower frequency in GBA mutation carries. In contrast, gait freezing and dysautonomia was present in lower frequencies in LRRK2 carriers. Besides that, LRRK2 and GBA mutation carriers showed a higher incidence of depressive symptoms and a younger age at onset, when compared to non-carriers.Our results suggest that specific mutations in GBA and LRRK2 influence the clinical signs of the disease, with significant implications for handling of specific patient groups." @default.
• W2745324069 created "2017-08-31" @default.
• W2745324069 creator A5000801327 @default.
• W2745324069 creator A5001191727 @default.
• W2745324069 creator A5001564413 @default.
• W2745324069 creator A5002249765 @default.
• W2745324069 creator A5022112329 @default.
• W2745324069 creator A5022830520 @default.
• W2745324069 creator A5024679194 @default.
• W2745324069 creator A5031244762 @default.
• W2745324069 creator A5039319213 @default.
• W2745324069 creator A5050519648 @default.
• W2745324069 creator A5050656388 @default.
• W2745324069 creator A5055820609 @default.
• W2745324069 creator A5057706712 @default.
• W2745324069 creator A5059779738 @default.
• W2745324069 creator A5063931764 @default.
• W2745324069 creator A5067848218 @default.
• W2745324069 creator A5068740606 @default.
• W2745324069 creator A5070217464 @default.
• W2745324069 creator A5078847940 @default.
• W2745324069 creator A5081334802 @default.
• W2745324069 creator A5090613835 @default.
• W2745324069 date "2017-10-01" @default.
• W2745324069 modified "2023-10-09" @default.
• W2745324069 title "Clinical profiles associated with LRRK2 and GBA mutations in Brazilians with Parkinson's disease" @default.
• W2745324069 cites W1536950205 @default.
• W2745324069 cites W1558427337 @default.
• W2745324069 cites W1855979424 @default.
• W2745324069 cites W1929210519 @default.
• W2745324069 cites W1976677339 @default.
• W2745324069 cites W1977507023 @default.
• W2745324069 cites W1979883589 @default.
• W2745324069 cites W1984663539 @default.
• W2745324069 cites W1992253341 @default.
• W2745324069 cites W2001307857 @default.
• W2745324069 cites W2008560062 @default.
• W2745324069 cites W2017544000 @default.
• W2745324069 cites W2024123655 @default.
• W2745324069 cites W2039304191 @default.
• W2745324069 cites W2047886023 @default.
• W2745324069 cites W2054863974 @default.
• W2745324069 cites W2097777783 @default.
• W2745324069 cites W2100600161 @default.
• W2745324069 cites W2102225317 @default.
• W2745324069 cites W2103749983 @default.
• W2745324069 cites W2113824125 @default.
• W2745324069 cites W2120398433 @default.
• W2745324069 cites W2131251654 @default.
• W2745324069 cites W2131476886 @default.
• W2745324069 cites W2138809212 @default.
• W2745324069 cites W2139351852 @default.
• W2745324069 cites W2145515423 @default.
• W2745324069 cites W2157765536 @default.
• W2745324069 cites W2165400844 @default.
• W2745324069 cites W2167299318 @default.
• W2745324069 cites W2170281382 @default.
• W2745324069 cites W2397744079 @default.
• W2745324069 cites W2509904505 @default.
• W2745324069 cites W2537216498 @default.
• W2745324069 cites W2576899661 @default.
• W2745324069 cites W2595455544 @default.
• W2745324069 cites W2748541962 @default.
• W2745324069 cites W4211044101 @default.
• W2745324069 cites W4296022821 @default.
• W2745324069 doi "https://doi.org/10.1016/j.jns.2017.08.3249" @default.
• W2745324069 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28991672" @default.
• W2745324069 hasPublicationYear "2017" @default.
• W2745324069 type Work @default.
• W2745324069 sameAs 2745324069 @default.
• W2745324069 citedByCount "17" @default.
• W2745324069 countsByYear W27453240692018 @default.
• W2745324069 countsByYear W27453240692019 @default.
• W2745324069 countsByYear W27453240692020 @default.
• W2745324069 countsByYear W27453240692021 @default.
• W2745324069 countsByYear W27453240692022 @default.
• W2745324069 countsByYear W27453240692023 @default.
• W2745324069 crossrefType "journal-article" @default.
• W2745324069 hasAuthorship W2745324069A5000801327 @default.
• W2745324069 hasAuthorship W2745324069A5001191727 @default.
• W2745324069 hasAuthorship W2745324069A5001564413 @default.
• W2745324069 hasAuthorship W2745324069A5002249765 @default.
• W2745324069 hasAuthorship W2745324069A5022112329 @default.
• W2745324069 hasAuthorship W2745324069A5022830520 @default.
• W2745324069 hasAuthorship W2745324069A5024679194 @default.
• W2745324069 hasAuthorship W2745324069A5031244762 @default.
• W2745324069 hasAuthorship W2745324069A5039319213 @default.
• W2745324069 hasAuthorship W2745324069A5050519648 @default.
• W2745324069 hasAuthorship W2745324069A5050656388 @default.
• W2745324069 hasAuthorship W2745324069A5055820609 @default.
• W2745324069 hasAuthorship W2745324069A5057706712 @default.
• W2745324069 hasAuthorship W2745324069A5059779738 @default.
• W2745324069 hasAuthorship W2745324069A5063931764 @default.
• W2745324069 hasAuthorship W2745324069A5067848218 @default.
• W2745324069 hasAuthorship W2745324069A5068740606 @default.
• W2745324069 hasAuthorship W2745324069A5070217464 @default.
• W2745324069 hasAuthorship W2745324069A5078847940 @default.
• W2745324069 hasAuthorship W2745324069A5081334802 @default.

• next