FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2745324412> ?p ?o ?g. }

• W2745324412 abstract "Titrimetric and spectrophotometric methods, two each, are described for the assay of promethazine hydrochloride (PH) in bulk drug and in dosage forms using N-chlorosuccinimide (NCS) and two dyes, methyl orange and indigo carmine as reagents. In direct titrimetry (method A), aqueous solution of PH is titrated directly with a standard solution of NCS in acid medium and in the presence of potassium bromide (KBr). Indirect titration (method B) involves the addition of a measured excess of standard NCS to PH solution in acid medium followed by iodometric back titration of unreacted oxidant. Spectrophotometric methods entail the addition of a known excess of NCS to a solution of PH in acid medium and in the presence of KBr followed by determination of residual bromine by reaction with a fixed amount of either methyl orange and measuring the absorbance at 520 nm (method C) or indigo carmine and measuring the absorbance at 610 nm (method D). In all the methods, the amount of NCS reacted corresponds to the amount of PH. In both titrimetric methods, the reaction stoichiometry was found to be 1:1 (PH : NCS) and are applicable over 2-20 mg (method A) and 1.5- 10 mg (method B) ranges. In spectrophotometric methods, the absorbance was found increase linearly with the correlation coefficients of 0.9998 and 0.9995 for method C and method D, respectively. The systems obey Beer’s law for 0.5-6.0 μg/ml (method C) and 1-10 μg/ml (method D). The calculated apparent molar absorptivity values are found to be 3.92 ×104 and 1.69 ×104 l/mol/cm for method C and method D, respectively, and the corresponding Sandell sensitivity values are 0.0082 and 0.0019 μg/cm2. The limits of detection and quantification are reported for both spectrophotometric methods. Intraday and inter-day precision and accuracy of the methods were evaluated as per ICH guidelines. The methods were successfully applied to the determination of PH in tablets, injections and syrup, and the results were statistically compared with those of a reference method by applying Student’s t- and F-tests. No interference was observed from common additives and excipients found in dosage forms. The accuracy and reliability of the methods were further ascertained by performing recovery test via standard addition method." @default.
• W2745324412 created "2017-08-31" @default.
• W2745324412 creator A5035859330 @default.
• W2745324412 creator A5079163028 @default.
• W2745324412 creator A5081535672 @default.
• W2745324412 creator A5088546331 @default.
• W2745324412 date "2007-12-01" @default.
• W2745324412 modified "2023-09-23" @default.
• W2745324412 title "New Titrimetric And Spectrophotometric Methods For The Assay Of Promethazine In Pharmaceuticals Using N-Chlorosuccinimide And Two Dyes" @default.
• W2745324412 hasPublicationYear "2007" @default.
• W2745324412 type Work @default.
• W2745324412 sameAs 2745324412 @default.
• W2745324412 citedByCount "1" @default.
• W2745324412 countsByYear W27453244122019 @default.
• W2745324412 crossrefType "journal-article" @default.
• W2745324412 hasAuthorship W2745324412A5035859330 @default.
• W2745324412 hasAuthorship W2745324412A5079163028 @default.
• W2745324412 hasAuthorship W2745324412A5081535672 @default.
• W2745324412 hasAuthorship W2745324412A5088546331 @default.
• W2745324412 hasConcept C119128265 @default.
• W2745324412 hasConcept C120665830 @default.
• W2745324412 hasConcept C121332964 @default.
• W2745324412 hasConcept C13965031 @default.
• W2745324412 hasConcept C14538495 @default.
• W2745324412 hasConcept C161790260 @default.
• W2745324412 hasConcept C178790620 @default.
• W2745324412 hasConcept C179104552 @default.
• W2745324412 hasConcept C184651966 @default.
• W2745324412 hasConcept C184866935 @default.
• W2745324412 hasConcept C185592680 @default.
• W2745324412 hasConcept C187621214 @default.
• W2745324412 hasConcept C196765960 @default.
• W2745324412 hasConcept C2353230 @default.
• W2745324412 hasConcept C2779174523 @default.
• W2745324412 hasConcept C2779378151 @default.
• W2745324412 hasConcept C2780343419 @default.
• W2745324412 hasConcept C2780780826 @default.
• W2745324412 hasConcept C2781307518 @default.
• W2745324412 hasConcept C40875361 @default.
• W2745324412 hasConcept C43617362 @default.
• W2745324412 hasConcept C65165184 @default.
• W2745324412 hasConcept C76046532 @default.
• W2745324412 hasConcept C98015330 @default.
• W2745324412 hasConceptScore W2745324412C119128265 @default.
• W2745324412 hasConceptScore W2745324412C120665830 @default.
• W2745324412 hasConceptScore W2745324412C121332964 @default.
• W2745324412 hasConceptScore W2745324412C13965031 @default.
• W2745324412 hasConceptScore W2745324412C14538495 @default.
• W2745324412 hasConceptScore W2745324412C161790260 @default.
• W2745324412 hasConceptScore W2745324412C178790620 @default.
• W2745324412 hasConceptScore W2745324412C179104552 @default.
• W2745324412 hasConceptScore W2745324412C184651966 @default.
• W2745324412 hasConceptScore W2745324412C184866935 @default.
• W2745324412 hasConceptScore W2745324412C185592680 @default.
• W2745324412 hasConceptScore W2745324412C187621214 @default.
• W2745324412 hasConceptScore W2745324412C196765960 @default.
• W2745324412 hasConceptScore W2745324412C2353230 @default.
• W2745324412 hasConceptScore W2745324412C2779174523 @default.
• W2745324412 hasConceptScore W2745324412C2779378151 @default.
• W2745324412 hasConceptScore W2745324412C2780343419 @default.
• W2745324412 hasConceptScore W2745324412C2780780826 @default.
• W2745324412 hasConceptScore W2745324412C2781307518 @default.
• W2745324412 hasConceptScore W2745324412C40875361 @default.
• W2745324412 hasConceptScore W2745324412C43617362 @default.
• W2745324412 hasConceptScore W2745324412C65165184 @default.
• W2745324412 hasConceptScore W2745324412C76046532 @default.
• W2745324412 hasConceptScore W2745324412C98015330 @default.
• W2745324412 hasIssue "2" @default.
• W2745324412 hasLocation W27453244121 @default.
• W2745324412 hasOpenAccess W2745324412 @default.
• W2745324412 hasPrimaryLocation W27453244121 @default.
• W2745324412 hasRelatedWork W115181701 @default.
• W2745324412 hasRelatedWork W1512337044 @default.
• W2745324412 hasRelatedWork W1613754998 @default.
• W2745324412 hasRelatedWork W2019943347 @default.
• W2745324412 hasRelatedWork W2020532392 @default.
• W2745324412 hasRelatedWork W2045452590 @default.
• W2745324412 hasRelatedWork W2071727090 @default.
• W2745324412 hasRelatedWork W2144055101 @default.
• W2745324412 hasRelatedWork W2944850626 @default.
• W2745324412 hasRelatedWork W2986617950 @default.
• W2745324412 hasRelatedWork W562634984 @default.
• W2745324412 hasRelatedWork W62072693 @default.
• W2745324412 hasRelatedWork W78299053 @default.
• W2745324412 hasRelatedWork W102013489 @default.
• W2745324412 hasRelatedWork W175424003 @default.
• W2745324412 hasRelatedWork W184741881 @default.
• W2745324412 hasRelatedWork W185660289 @default.
• W2745324412 hasRelatedWork W20260175 @default.
• W2745324412 hasRelatedWork W2183652454 @default.
• W2745324412 hasRelatedWork W3147882197 @default.
• W2745324412 hasVolume "4" @default.
• W2745324412 isParatext "false" @default.
• W2745324412 isRetracted "false" @default.
• W2745324412 magId "2745324412" @default.
• W2745324412 workType "article" @default.