FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2745363723> ?p ?o ?g. }

• W2745363723 abstract "Arterial thrombosis plays a key role in cardiovascular diseases. Hence, developing more effective antithrombotic agents is necessary. We designed a ruthenium (II)-derived complex, [Ru(η6-cymene)2-(1H-benzoimidazol-2-yl)-quinoline Cl]BF4 (TQ-6), as a new antiplatelet drug. TQ-6 (0.3 µM) exhibited extremely strong inhibitory activity against platelet aggregation, Src, and Syk phosphorylation stimulated by agonists in human platelets. In collagen-activated platelets, TQ-6 also inhibited ATP-release, [Ca+2]i, P-selectin expression, FITC-PAC-1 binding, and hydroxyl radical formation, as well as the phosphorylation of phospholipase Cγ2, protein kinase C, mitogen-activated protein kinases, and Akt. Neither FITC-JAQ1 nor FITC-triflavin binding or integrin β3 phosphorylation stimulated by immobilized fibrinogen were diminished by TQ-6. Furthermore, TQ-6 had no effects in cyclic nucleotide formation. Moreover, TQ-6 substantially prolonged the closure time in whole blood, increased the occlusion time of thrombotic platelet plug formation and bleeding time in mice. In conclusion, TQ-6 has a novel role in inhibiting platelet activation through the inhibition of the agonist receptors-mediated inside-out signaling such as Src-Syk-PLCγ2 cascade and subsequent suppression of granule secretion, leading to disturb integrin αIIbβ3-mediated outside-in signaling, and ultimately inhibiting platelet aggregation. Therefore, TQ-6 has potential to develop as a therapeutic agent for preventing or treating thromboembolic disorders." @default.
• W2745363723 created "2017-08-31" @default.
• W2745363723 creator A5020206418 @default.
• W2745363723 creator A5021610721 @default.
• W2745363723 creator A5022184391 @default.
• W2745363723 creator A5025047436 @default.
• W2745363723 creator A5032789979 @default.
• W2745363723 creator A5049614595 @default.
• W2745363723 creator A5051172285 @default.
• W2745363723 creator A5067249394 @default.
• W2745363723 date "2017-08-25" @default.
• W2745363723 modified "2023-09-24" @default.
• W2745363723 title "A novel ruthenium (II)-derived organometallic compound, TQ-6, potently inhibits platelet aggregation: Ex vivo and in vivo studies" @default.
• W2745363723 cites W119510731 @default.
• W2745363723 cites W1784331147 @default.
• W2745363723 cites W1964095591 @default.
• W2745363723 cites W1968258743 @default.
• W2745363723 cites W1968497165 @default.
• W2745363723 cites W1976320326 @default.
• W2745363723 cites W1978341139 @default.
• W2745363723 cites W1988212011 @default.
• W2745363723 cites W1996247217 @default.
• W2745363723 cites W1996405087 @default.
• W2745363723 cites W2008935174 @default.
• W2745363723 cites W2012165211 @default.
• W2745363723 cites W2014769233 @default.
• W2745363723 cites W2028362773 @default.
• W2745363723 cites W2029325522 @default.
• W2745363723 cites W2051353946 @default.
• W2745363723 cites W2053228115 @default.
• W2745363723 cites W2053305824 @default.
• W2745363723 cites W2061827331 @default.
• W2745363723 cites W2070066401 @default.
• W2745363723 cites W2081995432 @default.
• W2745363723 cites W2087520911 @default.
• W2745363723 cites W2094652341 @default.
• W2745363723 cites W2103205445 @default.
• W2745363723 cites W2108349218 @default.
• W2745363723 cites W2112919363 @default.
• W2745363723 cites W2126142444 @default.
• W2745363723 cites W2128139337 @default.
• W2745363723 cites W2135237523 @default.
• W2745363723 cites W2135820180 @default.
• W2745363723 cites W2140784465 @default.
• W2745363723 cites W2150398483 @default.
• W2745363723 cites W2165938620 @default.
• W2745363723 cites W2208023807 @default.
• W2745363723 cites W2322751526 @default.
• W2745363723 cites W2418178293 @default.
• W2745363723 cites W2418427966 @default.
• W2745363723 cites W56507834 @default.
• W2745363723 doi "https://doi.org/10.1038/s41598-017-09695-z" @default.
• W2745363723 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5573325" @default.
• W2745363723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28842683" @default.
• W2745363723 hasPublicationYear "2017" @default.
• W2745363723 type Work @default.
• W2745363723 sameAs 2745363723 @default.
• W2745363723 citedByCount "13" @default.
• W2745363723 countsByYear W27453637232018 @default.
• W2745363723 countsByYear W27453637232019 @default.
• W2745363723 countsByYear W27453637232020 @default.
• W2745363723 countsByYear W27453637232021 @default.
• W2745363723 countsByYear W27453637232022 @default.
• W2745363723 countsByYear W27453637232023 @default.
• W2745363723 crossrefType "journal-article" @default.
• W2745363723 hasAuthorship W2745363723A5020206418 @default.
• W2745363723 hasAuthorship W2745363723A5021610721 @default.
• W2745363723 hasAuthorship W2745363723A5022184391 @default.
• W2745363723 hasAuthorship W2745363723A5025047436 @default.
• W2745363723 hasAuthorship W2745363723A5032789979 @default.
• W2745363723 hasAuthorship W2745363723A5049614595 @default.
• W2745363723 hasAuthorship W2745363723A5051172285 @default.
• W2745363723 hasAuthorship W2745363723A5067249394 @default.
• W2745363723 hasBestOaLocation W27453637231 @default.
• W2745363723 hasConcept C108636557 @default.
• W2745363723 hasConcept C11960822 @default.
• W2745363723 hasConcept C126322002 @default.
• W2745363723 hasConcept C170493617 @default.
• W2745363723 hasConcept C185592680 @default.
• W2745363723 hasConcept C195687474 @default.
• W2745363723 hasConcept C202751555 @default.
• W2745363723 hasConcept C26291073 @default.
• W2745363723 hasConcept C2777628954 @default.
• W2745363723 hasConcept C2909112448 @default.
• W2745363723 hasConcept C3018697912 @default.
• W2745363723 hasConcept C35174551 @default.
• W2745363723 hasConcept C42362537 @default.
• W2745363723 hasConcept C55493867 @default.
• W2745363723 hasConcept C62478195 @default.
• W2745363723 hasConcept C71924100 @default.
• W2745363723 hasConcept C86803240 @default.
• W2745363723 hasConcept C89560881 @default.
• W2745363723 hasConcept C95444343 @default.
• W2745363723 hasConcept C98274493 @default.
• W2745363723 hasConceptScore W2745363723C108636557 @default.
• W2745363723 hasConceptScore W2745363723C11960822 @default.
• W2745363723 hasConceptScore W2745363723C126322002 @default.
• W2745363723 hasConceptScore W2745363723C170493617 @default.
• W2745363723 hasConceptScore W2745363723C185592680 @default.
• W2745363723 hasConceptScore W2745363723C195687474 @default.

• next