FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2745415184> ?p ?o ?g. }

• W2745415184 endingPage "8" @default.
• W2745415184 startingPage "1" @default.
• W2745415184 abstract "The intertwining between cancer pathogenesis and perturbation of multitude signaling pathways ushered the cancer therapeutic approaches into an unbounded route of targeted therapies. For the nonce and among the plethora of promising inhibitors, intense interest has focused on small molecules targeting different component of PI3K axis. Intrigued by the constant activation of PI3K in leukemia, this study aimed to investigate the effects of BKM120, as the excelled member of pan PI3K inhibitors, in a panel of hematologic malignant cell lines. The resulting data showed that BKM120 exerted a concentration-dependent growth suppressive effect; however, IC50 values varied among the tested cells. Our results outlined that the blockage of PI3K in NB4, as the most sensitive cell line, resulted in a caspase-3-dependent apoptosis probably through NFκB-mediated suppression of c-Myc and hTERT. As far we are aware, to date, there have been no reports of BKM120 effect on enzymatic repression of telomerase, and this study represents for the first time that the anti-proliferative effect of the inhibitor on NB4 is mediated by down-regulation of telomerase; shedding new light on the novel mechanism of action of BKM120." @default.
• W2745415184 created "2017-08-31" @default.
• W2745415184 creator A5023236506 @default.
• W2745415184 creator A5036536670 @default.
• W2745415184 creator A5055007472 @default.
• W2745415184 creator A5066883249 @default.
• W2745415184 creator A5076707279 @default.
• W2745415184 creator A5090828119 @default.
• W2745415184 date "2017-10-01" @default.
• W2745415184 modified "2023-09-23" @default.
• W2745415184 title "Novel pan PI3K inhibitor-induced apoptosis in APL cells correlates with suppression of telomerase: An emerging mechanism of action of BKM120" @default.
• W2745415184 cites W1595724240 @default.
• W2745415184 cites W1965627667 @default.
• W2745415184 cites W1974300980 @default.
• W2745415184 cites W2003560510 @default.
• W2745415184 cites W2013651297 @default.
• W2745415184 cites W2018326038 @default.
• W2745415184 cites W2028859420 @default.
• W2745415184 cites W2045025607 @default.
• W2745415184 cites W2047994338 @default.
• W2745415184 cites W2049396238 @default.
• W2745415184 cites W2052586881 @default.
• W2745415184 cites W2065825082 @default.
• W2745415184 cites W2087861588 @default.
• W2745415184 cites W2089277080 @default.
• W2745415184 cites W2102839088 @default.
• W2745415184 cites W2117263216 @default.
• W2745415184 cites W2126850174 @default.
• W2745415184 cites W2129242642 @default.
• W2745415184 cites W2131888987 @default.
• W2745415184 cites W2145028653 @default.
• W2745415184 cites W2145329958 @default.
• W2745415184 cites W2149517207 @default.
• W2745415184 cites W2153272770 @default.
• W2745415184 cites W2164487353 @default.
• W2745415184 cites W2165404212 @default.
• W2745415184 cites W2167746858 @default.
• W2745415184 cites W2172375845 @default.
• W2745415184 cites W2208333084 @default.
• W2745415184 cites W2216220486 @default.
• W2745415184 cites W2217019432 @default.
• W2745415184 cites W2229509093 @default.
• W2745415184 cites W2238997491 @default.
• W2745415184 cites W2388163742 @default.
• W2745415184 cites W2403219295 @default.
• W2745415184 cites W2508561977 @default.
• W2745415184 cites W2561471811 @default.
• W2745415184 cites W2580397538 @default.
• W2745415184 cites W2589489346 @default.
• W2745415184 cites W2615838222 @default.
• W2745415184 cites W918937935 @default.
• W2745415184 doi "https://doi.org/10.1016/j.biocel.2017.08.009" @default.
• W2745415184 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28834761" @default.
• W2745415184 hasPublicationYear "2017" @default.
• W2745415184 type Work @default.
• W2745415184 sameAs 2745415184 @default.
• W2745415184 citedByCount "14" @default.
• W2745415184 countsByYear W27454151842018 @default.
• W2745415184 countsByYear W27454151842019 @default.
• W2745415184 countsByYear W27454151842020 @default.
• W2745415184 countsByYear W27454151842021 @default.
• W2745415184 crossrefType "journal-article" @default.
• W2745415184 hasAuthorship W2745415184A5023236506 @default.
• W2745415184 hasAuthorship W2745415184A5036536670 @default.
• W2745415184 hasAuthorship W2745415184A5055007472 @default.
• W2745415184 hasAuthorship W2745415184A5066883249 @default.
• W2745415184 hasAuthorship W2745415184A5076707279 @default.
• W2745415184 hasAuthorship W2745415184A5090828119 @default.
• W2745415184 hasConcept C104317684 @default.
• W2745415184 hasConcept C150194340 @default.
• W2745415184 hasConcept C185592680 @default.
• W2745415184 hasConcept C186310378 @default.
• W2745415184 hasConcept C190283241 @default.
• W2745415184 hasConcept C202751555 @default.
• W2745415184 hasConcept C2776120743 @default.
• W2745415184 hasConcept C502942594 @default.
• W2745415184 hasConcept C54355233 @default.
• W2745415184 hasConcept C62478195 @default.
• W2745415184 hasConcept C86554907 @default.
• W2745415184 hasConcept C86803240 @default.
• W2745415184 hasConcept C94581717 @default.
• W2745415184 hasConcept C95444343 @default.
• W2745415184 hasConceptScore W2745415184C104317684 @default.
• W2745415184 hasConceptScore W2745415184C150194340 @default.
• W2745415184 hasConceptScore W2745415184C185592680 @default.
• W2745415184 hasConceptScore W2745415184C186310378 @default.
• W2745415184 hasConceptScore W2745415184C190283241 @default.
• W2745415184 hasConceptScore W2745415184C202751555 @default.
• W2745415184 hasConceptScore W2745415184C2776120743 @default.
• W2745415184 hasConceptScore W2745415184C502942594 @default.
• W2745415184 hasConceptScore W2745415184C54355233 @default.
• W2745415184 hasConceptScore W2745415184C62478195 @default.
• W2745415184 hasConceptScore W2745415184C86554907 @default.
• W2745415184 hasConceptScore W2745415184C86803240 @default.
• W2745415184 hasConceptScore W2745415184C94581717 @default.
• W2745415184 hasConceptScore W2745415184C95444343 @default.
• W2745415184 hasLocation W27454151841 @default.
• W2745415184 hasLocation W27454151842 @default.

• next