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- W2745431718 abstract "Myocardial heterogeneities at the microstructural level are likely to play important roles in electrical conduction, arrhythmogenesis, and anti-arrhythmic therapy. However, due to a lack in appropriate experimental methodologies, their role has not been thoroughly explored and their contribution to cardiac electrical behaviour has not been quantified. The goal of this project was to develop the first high-resolution model of cardiac microstructure that can be used in studies of arrhythmogenesis and defibrillation. Specifically, the project focused on the development of a finite-element bidomain microstructure model of a left ventricular (LV) wedge from the rabbit heart. Such a model will be invaluable for studies of arrhythmia initiation mechanisms associated with normal or pathological (fibrosis) heterogeneities in the heart, as well as for research into defibrillation mechanisms, where the role of micro-heterogeneities in the formation of shock-induced virtual electrode polarization has been suspected, but not fully understood. The present microanatomically-detailed finite-element model of a rabbit LV wedge preparation was built from high resolution (25-30 μm) MRI data (11.7 T). The MRI stack was segmented via gray level thresholding and morphological operations (see Figure, segmented stack), and fiber directions were estimated, based on the structure tensor. An octree-based meshing technique producing boundary-fitted, locally-refined and conformal multi-element meshes was applied; the resulting mesh of the wedge is presented in the Figure. A cut through the mesh exposes the presence of structural micro-heterogeneities (Figure). A paced propagation through the wedge model, in which the myocardium is represented as a bidomain is also shown (Figure). This demonstrates the feasibility of this approach for studying arrhythmogenesis and defibrillation." @default.
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- W2745431718 date "2006-05-01" @default.
- W2745431718 modified "2023-09-23" @default.
- W2745431718 title "P1-13" @default.
- W2745431718 doi "https://doi.org/10.1016/j.hrthm.2006.02.336" @default.
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