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• W2745492072 abstract "Abstract Introduction In recent genome-wide association studies, coronary artery disease (CAD) and myocardial infarction (MI) have been linked to a number of genetic variants, but their role in thrombopoiesis is largely unknown. Aim We investigated the association between CAD and MI-associated genetic variants and five thrombopoiesis-related indices: platelet count (PC), mean platelet volume (MPV), immature platelet count (IPC), immature platelet fraction (IPF), and serum thrombopoietin (TPO). Methods We genotyped 45 genome-wide significant CAD/MI-markers in 879 stable CAD patients. A genetic risk score was calculated to assess the combined risk associated with all the genetic variants. Platelet indices were analysed using the Sysmex XE-2100 haematology analyser. TPO was measured by ELISA. Results Two variants were nominally associated with several indices; for rs10947789 (KCNK5), the adjusted geometric mean was 2% higher for MPV (95% confidence interval: 1–2%, p = 0.002), 6% for IPC (0–12%, p = 0.033), and 9% for IPF (3–16%, p = 0.004) per CAD risk allele. Moreover, an 11% lower TPO (3–19%, p = 0.010) was observed. Rs3184504 (SH2B3) was associated with a higher adjusted geometric mean of 3% (1–6%, p = 0.003) per CAD risk allele for PC, and an 11% (5–17%, p  Conclusion As a novel finding, our study suggests a role for KCNK5 in the regulation of platelet size and maturity. Furthermore, our findings confirm an association between the SH2B3-locus and platelet count." @default.
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• W2745492072 date "2017-10-01" @default.
• W2745492072 modified "2023-09-23" @default.
• W2745492072 title "The SH2B3 and KCNK5 loci may be implicated in regulation of platelet count, volume, and maturity" @default.
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• W2745492072 doi "https://doi.org/10.1016/j.thromres.2017.08.009" @default.
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