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- W2745642711 abstract "Objective To determine effects of propofol combined with diazepam on GABA-activated chloride currents(IGABA). Methods Whole-cell patch clamp recordings were made from cultured rat dorsal root ganglionic neurons dissociated by collagenase and trypsin, and trituration. 3 μmol/L GABA was administered by pressure ejection, meanwhile, propofol and diazepam were dissolved in the external solution and were given with the Y tube technique. Results Co-application of propofol(0.3, 1.0, 3.0μmol/L) and diazepam (100 nmol/L) potentiated the IGABA ,which was significantly larger than the sum of that potentiated by either drug alone. Diazepam (100 nmol/L ) shifted the concentration-response curve of the propofol-potentiated IGABA to the left in parallel fasion, the EC50 value of propofol was decreased by diazepam from (7.6 ±1.8) μmol/L to (3.9±1.1 )μmol/L.Conclusions Propofol combined with diazepam synergistically potentiates GABA-gated chloride currents in rat sensory neurons." @default.
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- W2745642711 date "1994-01-01" @default.
- W2745642711 modified "2023-09-25" @default.
- W2745642711 title "Propofol combined with diazepam synergistically potentiates the GABA-activated chloride current in rat sensory neurons" @default.
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