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• W2745738325 endingPage "883" @default.
• W2745738325 startingPage "883" @default.
• W2745738325 abstract "Alzheimer's disease (AD) is a fatal neurodegenerative disease. Brain amyloid-β deposition is a crucial feature of AD, causing neuronal cell death by inducing oxidative damage. Reactive oxygen species (ROS) activate NF-κB, which induces expression of Nucling. Nucling is a pro-apoptotic factor recruiting the apoptosome complex. Lycopene is an antioxidant protecting from oxidative stress-induced cell damage. We investigated whether lycopene inhibits amyloid-β-stimulated apoptosis through reducing ROS and inhibiting mitochondrial dysfunction and NF-κB-mediated Nucling expression in neuronal SH-SY5Y cells. We prepared cells transfected with siRNA for Nucling or nontargeting control siRNA to determine the role of Nucling in amyloid-β-induced apoptosis. The amyloid-β increased intracellular and mitochondrial ROS levels, apoptotic indices (p53, Bax/Bcl-2 ratio, caspase-3 cleavage), NF-kB activation and Nucling expression, while cell viability, mitochondrial membrane potential, and oxygen consumption rate decreased in SH-SY5Y cells. Lycopene inhibited these amyloid-β-induced alterations. However, amyloid-β did not induce apoptosis, determined by cell viability and apoptotic indices (p53, Bax/Bcl-2 ratio, caspase-3 cleavage), in the cells transfected with siRNA for Nucling. Lycopene inhibited apoptosis by reducing ROS, and by inhibiting mitochondrial dysfunction and NF-κB-target gene Nucling expression in neuronal cells. Lycopene may be beneficial for preventing oxidative stress-mediated neuronal death in patients with neurodegeneration." @default.
• W2745738325 created "2017-08-31" @default.
• W2745738325 creator A5029929216 @default.
• W2745738325 creator A5038069069 @default.
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• W2745738325 date "2017-08-16" @default.
• W2745738325 modified "2023-09-26" @default.
• W2745738325 title "Inhibitory Effect of Lycopene on Amyloid-β-Induced Apoptosis in Neuronal Cells" @default.
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• W2745738325 doi "https://doi.org/10.3390/nu9080883" @default.
• W2745738325 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5579676" @default.
• W2745738325 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28813012" @default.
• W2745738325 hasPublicationYear "2017" @default.
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