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• W2745827302 startingPage "1423" @default.
• W2745827302 abstract "Type 2 diabetes is characterized by insulin resistance, which leads to increased blood glucose levels. Adipocytes are involved in the development of insulin resistance, resulting from the dysfunction of the insulin signaling pathway. In this study, we investigated whether meso-dihydroguaiaretic acid (MDGA) may modulate glucose uptake in adipocytes, and examined its mechanism of action. MDGA enhanced adipogenesis through up-regulation of peroxisome proliferator-activated receptor γ and CCAAT/enhancer-binding protein α in 3T3-L1 adipocytes partially differentiated with sub-optimal concentrations of insulin. MDGA also increased glucose uptake by stimulating expression and translocation of glucose transporter 4 (GLUT4) in adipocytes. These results suggest that MDGA may increase GLUT4 expression and its translocation by promoting insulin sensitivity, leading to enhanced glucose uptake." @default.
• W2745827302 created "2017-08-31" @default.
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• W2745827302 date "2017-08-28" @default.
• W2745827302 modified "2023-10-01" @default.
• W2745827302 title "Enhancement of Glucose Uptake by Meso-Dihydroguaiaretic Acid through GLUT4 Up-Regulation in 3T3-L1 Adipocytes" @default.
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• W2745827302 doi "https://doi.org/10.3390/molecules22091423" @default.
• W2745827302 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6151792" @default.
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