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• W2745848511 endingPage "2913" @default.
• W2745848511 startingPage "2907" @default.
• W2745848511 abstract "In this study, we have prepared a self-cross-linking PEG-based branched polymer, which easily forms a bioreducible nanoshell around polyplexes of cationic polymer and DNA, simply via heating the polyplex dispersions in the presence of this self-cross-linking branched polymer. This nanoshell can prevent the polyplex from dissociation and aggregation in physiological fluids without inhibiting the electrostatic interactions between the polymer and DNA. Furthermore, glutathione (GSH) can act as a stimulus to open the nanoshell after it has entered the cell. The polyplexes coated with the bioreducible nanoshell show an obvious enhancement in gene transfection in vivo compared with bare polyplexes." @default.
• W2745848511 created "2017-08-31" @default.
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• W2745848511 date "2014-07-07" @default.
• W2745848511 modified "2023-10-16" @default.
• W2745848511 title "Bioreducible Cross-Linked Nanoshell Enhances Gene Transfection of Polycation/DNA Polyplex in Vivo" @default.
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• W2745848511 doi "https://doi.org/10.1021/bm500518u" @default.
• W2745848511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24963863" @default.
• W2745848511 hasPublicationYear "2014" @default.
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