FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2745905806> ?p ?o ?g. }

• W2745905806 endingPage "e0183584" @default.
• W2745905806 startingPage "e0183584" @default.
• W2745905806 abstract "Retinoic acid receptor-related orphan nuclear receptor γt (RORγt) is a transcriptional factor responsible for IL-17-producing T-cell differentiation. Although it was demonstrated that RORγt plays essential roles in the onset of autoimmune myocarditis, pathophysiological significance of RORγt in cardiac remodeling after myocardial infarction (MI) remains to be fully elucidated.MI was generated by ligating coronary artery. The expression of RORγt and IL-17A transcripts increased in murine hearts after MI. Additionally, immunohistochemical staining revealed that RORγt-expressing cells infiltrated in the border zone after MI. Flow cytometric analysis showed that RORγt-expressing cells were released from the spleen at day 1 after MI. Though RORγt-expressing cells in spleen expressed γδTCR or CD4, γδTCR+ cells were major population of RORγt-expressing cells that infiltrated into post-infarct myocardium. To address the biological functions of RORγt-expressing cells in infarcted hearts, we used mice with enhanced GFP gene heterozygously knocked-in at RORγt locus (RORγt+/- mice), which physiologically showed reduced expression of RORγt mRNA in thymus. Kaplan-Meier analysis showed that MI-induced mortality was higher in RORγt+/- mice than wild-type (WT) mice. Masson's trichrome staining demonstrated that cardiac injury was exacerbated in RORγt+/- mice 7 days after MI (Injured area: RORγt+/-; 42.1±6.5%, WT; 34.0±3.7%, circumference of injured myocardium: RORγt+/-; 61.8±4.8%, WT; 49.6±5.1%), accompanied by exacerbation of cardiac function (fractional shortening: RORγt+/-; 32.9±2.9%, WT; 38.3±3.6%). Moreover, immunohistochemical analyses revealed that capillary density in border zone was significantly reduced in RORγt+/- mice after MI, compared with WT mice, associated with the reduced expression of angiopoietin 2. Finally, the mRNA expression of RORγt, IL-17A, IL-17F and IL-23 receptor (IL-23R) mRNA and protein expression of IL-10 were decreased in RORγt+/- hearts.Heterozygous deletion of RORγt gene resulted in aggravated cardiac remodeling, accompanied by reduced capillary density, after MI, suggesting that RORγt-expressing cells contribute to tissue repair in infarcted myocardium." @default.
• W2745905806 created "2017-08-31" @default.
• W2745905806 creator A5003500498 @default.
• W2745905806 creator A5014423509 @default.
• W2745905806 creator A5022699593 @default.
• W2745905806 creator A5058430581 @default.
• W2745905806 creator A5067114079 @default.
• W2745905806 creator A5079504532 @default.
• W2745905806 creator A5083862682 @default.
• W2745905806 creator A5086535576 @default.
• W2745905806 date "2017-08-21" @default.
• W2745905806 modified "2023-09-25" @default.
• W2745905806 title "RORγt-expressing cells attenuate cardiac remodeling after myocardial infarction" @default.
• W2745905806 cites W1488771302 @default.
• W2745905806 cites W1512693074 @default.
• W2745905806 cites W1913262543 @default.
• W2745905806 cites W1939997832 @default.
• W2745905806 cites W1964400031 @default.
• W2745905806 cites W1969184610 @default.
• W2745905806 cites W1971708477 @default.
• W2745905806 cites W1993569315 @default.
• W2745905806 cites W2005001270 @default.
• W2745905806 cites W2007861354 @default.
• W2745905806 cites W2016850513 @default.
• W2745905806 cites W2037994205 @default.
• W2745905806 cites W2039601697 @default.
• W2745905806 cites W2059044802 @default.
• W2745905806 cites W2072859659 @default.
• W2745905806 cites W2078558151 @default.
• W2745905806 cites W2088532961 @default.
• W2745905806 cites W2090622470 @default.
• W2745905806 cites W2095167461 @default.
• W2745905806 cites W2102370935 @default.
• W2745905806 cites W2102586246 @default.
• W2745905806 cites W2110499341 @default.
• W2745905806 cites W2111035891 @default.
• W2745905806 cites W2111451301 @default.
• W2745905806 cites W2123503904 @default.
• W2745905806 cites W2134012941 @default.
• W2745905806 cites W2139421164 @default.
• W2745905806 cites W2142017607 @default.
• W2745905806 cites W2145019007 @default.
• W2745905806 cites W2145655023 @default.
• W2745905806 cites W2150309776 @default.
• W2745905806 cites W2163532491 @default.
• W2745905806 cites W2167939087 @default.
• W2745905806 cites W2167962196 @default.
• W2745905806 cites W2169835977 @default.
• W2745905806 cites W2201210340 @default.
• W2745905806 cites W2229666266 @default.
• W2745905806 cites W2293669149 @default.
• W2745905806 cites W2776663677 @default.
• W2745905806 doi "https://doi.org/10.1371/journal.pone.0183584" @default.
• W2745905806 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5565178" @default.
• W2745905806 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28827845" @default.
• W2745905806 hasPublicationYear "2017" @default.
• W2745905806 type Work @default.
• W2745905806 sameAs 2745905806 @default.
• W2745905806 citedByCount "3" @default.
• W2745905806 countsByYear W27459058062018 @default.
• W2745905806 countsByYear W27459058062021 @default.
• W2745905806 crossrefType "journal-article" @default.
• W2745905806 hasAuthorship W2745905806A5003500498 @default.
• W2745905806 hasAuthorship W2745905806A5014423509 @default.
• W2745905806 hasAuthorship W2745905806A5022699593 @default.
• W2745905806 hasAuthorship W2745905806A5058430581 @default.
• W2745905806 hasAuthorship W2745905806A5067114079 @default.
• W2745905806 hasAuthorship W2745905806A5079504532 @default.
• W2745905806 hasAuthorship W2745905806A5083862682 @default.
• W2745905806 hasAuthorship W2745905806A5086535576 @default.
• W2745905806 hasBestOaLocation W27459058061 @default.
• W2745905806 hasConcept C104317684 @default.
• W2745905806 hasConcept C126322002 @default.
• W2745905806 hasConcept C134018914 @default.
• W2745905806 hasConcept C203014093 @default.
• W2745905806 hasConcept C2779161069 @default.
• W2745905806 hasConcept C2779727006 @default.
• W2745905806 hasConcept C2780875844 @default.
• W2745905806 hasConcept C2780931953 @default.
• W2745905806 hasConcept C500558357 @default.
• W2745905806 hasConcept C55493867 @default.
• W2745905806 hasConcept C71924100 @default.
• W2745905806 hasConcept C74737994 @default.
• W2745905806 hasConcept C86339819 @default.
• W2745905806 hasConcept C86803240 @default.
• W2745905806 hasConcept C8891405 @default.
• W2745905806 hasConceptScore W2745905806C104317684 @default.
• W2745905806 hasConceptScore W2745905806C126322002 @default.
• W2745905806 hasConceptScore W2745905806C134018914 @default.
• W2745905806 hasConceptScore W2745905806C203014093 @default.
• W2745905806 hasConceptScore W2745905806C2779161069 @default.
• W2745905806 hasConceptScore W2745905806C2779727006 @default.
• W2745905806 hasConceptScore W2745905806C2780875844 @default.
• W2745905806 hasConceptScore W2745905806C2780931953 @default.
• W2745905806 hasConceptScore W2745905806C500558357 @default.
• W2745905806 hasConceptScore W2745905806C55493867 @default.
• W2745905806 hasConceptScore W2745905806C71924100 @default.
• W2745905806 hasConceptScore W2745905806C74737994 @default.

• next