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- W2745914458 abstract "Fifty-onerheumatoid arthritis (RA) patients were enrolled to assess the gene expressionof tumor necrosis factor-alpha (TNF-α)by reverse transcription quantitative polymerase chain reaction (qRT-PCR) in etanercept-treated RA patients, with someemphasis on clinical and biological markers of disease. The results revealedthat the ΔCt mean range in total, male and female RA patients and controls was1.286 ± 1.226 - 4.023 ± 0.856 and the differences were not. Laboratory and clinicalfindings in subgroups of patients also showed no significant variations in thedistribution of 2-ΔΔCt means, with the exception of anti-cycliccitrullinated peptide (ACCP) antibodies. The lowest expression was observed inmoderate positive patients (1.566 ± 1.104) compared to low and high positivepatients (4.061 ± 1.366 and 9.668 ± 3.518, respectively) for ACCP antibodies,and the difference was significant (p = 0.043). Inspecting the 2-ΔΔCt means in duration of disease and gender revealed that male patients recorded alower mean than female patients (0.827 ± 0.550 vs. 4.143 ± 1.317) at10 years duration of disease, femalepatients showed a lower mean than male patients (1.242 ± 0.372 vs. 5.607± 3.334). However, both differences were not significant. It is concluded thatetanercept was effective in normalizing the TNF gene expression, but variations that were related to gender, duration ofdisease and some biological markers of disease, were observed." @default.
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- W2745914458 date "2017-01-01" @default.
- W2745914458 modified "2023-09-27" @default.
- W2745914458 title "Gene Expression of Tumor Necrosis Factor-Alpha in Etanercept-Treated Rheumatoid Arthritis Patients" @default.
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- W2745914458 doi "https://doi.org/10.4236/jbm.2017.59001" @default.
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