Matches in SemOpenAlex for { <https://semopenalex.org/work/W2745958223> ?p ?o ?g. }
- W2745958223 endingPage "178" @default.
- W2745958223 startingPage "139" @default.
- W2745958223 abstract "Since the molecular characterization of Drosophila midgut progenitors in 2006, a few hundred articles studying fly intestinal stem cells have already been published. There was a relative lag phase in creating new knowledge until 2009, when at least 20 papers per year started being published on the subject and at least 40 per year since 2013. Here, we ponder on the substantial literature prior to intestinal stem cell molecular identification, including intestinal stem cell development and evolutionary origin, and describe the milestones achieved since then with an emphasis on their impact on biomedical research. The existing literature illuminates aspects of intestinal stem cell function in terms of homeostasis and disease. We discuss key findings on (a) the genetic markers of stem cells, their asymmetric or symmetric divisions and their progeny, (b) signalling pathways or networks and organ communication, (c) bacterial infections and microbiota, (d) dietary factors and drugs and (e) ageing. The accumulated knowledge provides lessons relevant to intestinal hyperplasia, dysplasia and intestinal cell metastasis, signalling pathway integration, the role of regenerative inflammation in host defence and tumorigenesis, the role of diet and the potential for translational therapeutics through drugs against intestinal inflammation, tumours and ageing." @default.
- W2745958223 created "2017-08-31" @default.
- W2745958223 creator A5018367281 @default.
- W2745958223 creator A5019160525 @default.
- W2745958223 creator A5019377252 @default.
- W2745958223 creator A5071371857 @default.
- W2745958223 date "2017-01-01" @default.
- W2745958223 modified "2023-10-18" @default.
- W2745958223 title "Intestinal Stem Cells" @default.
- W2745958223 cites W145072841 @default.
- W2745958223 cites W1486393205 @default.
- W2745958223 cites W1496487857 @default.
- W2745958223 cites W1502391354 @default.
- W2745958223 cites W1505671001 @default.
- W2745958223 cites W1536803758 @default.
- W2745958223 cites W1573270171 @default.
- W2745958223 cites W1790041644 @default.
- W2745958223 cites W1795553829 @default.
- W2745958223 cites W1822171334 @default.
- W2745958223 cites W1891854262 @default.
- W2745958223 cites W1892259311 @default.
- W2745958223 cites W1934938631 @default.
- W2745958223 cites W1964684127 @default.
- W2745958223 cites W1968112233 @default.
- W2745958223 cites W1968814136 @default.
- W2745958223 cites W1969542174 @default.
- W2745958223 cites W1969837808 @default.
- W2745958223 cites W1970498241 @default.
- W2745958223 cites W1971903348 @default.
- W2745958223 cites W1972693900 @default.
- W2745958223 cites W1975473156 @default.
- W2745958223 cites W1977646726 @default.
- W2745958223 cites W1979893222 @default.
- W2745958223 cites W1980626846 @default.
- W2745958223 cites W1984479838 @default.
- W2745958223 cites W1985234259 @default.
- W2745958223 cites W1986364178 @default.
- W2745958223 cites W1986932941 @default.
- W2745958223 cites W1989459314 @default.
- W2745958223 cites W1989698811 @default.
- W2745958223 cites W1990063646 @default.
- W2745958223 cites W1991493591 @default.
- W2745958223 cites W1991691876 @default.
- W2745958223 cites W1993081168 @default.
- W2745958223 cites W1996776035 @default.
- W2745958223 cites W1996858055 @default.
- W2745958223 cites W1998741829 @default.
- W2745958223 cites W1999282770 @default.
- W2745958223 cites W2003731107 @default.
- W2745958223 cites W2004562554 @default.
- W2745958223 cites W2008826947 @default.
- W2745958223 cites W2010605216 @default.
- W2745958223 cites W2011599536 @default.
- W2745958223 cites W2012178564 @default.
- W2745958223 cites W2013123192 @default.
- W2745958223 cites W2015909273 @default.
- W2745958223 cites W2017520829 @default.
- W2745958223 cites W2019321342 @default.
- W2745958223 cites W2019424268 @default.
- W2745958223 cites W2019743003 @default.
- W2745958223 cites W2020355568 @default.
- W2745958223 cites W2021370278 @default.
- W2745958223 cites W2022374483 @default.
- W2745958223 cites W2023351030 @default.
- W2745958223 cites W2023649138 @default.
- W2745958223 cites W2024646477 @default.
- W2745958223 cites W2025863678 @default.
- W2745958223 cites W2028133785 @default.
- W2745958223 cites W2028539250 @default.
- W2745958223 cites W2030791386 @default.
- W2745958223 cites W2030896914 @default.
- W2745958223 cites W2031217639 @default.
- W2745958223 cites W2031442063 @default.
- W2745958223 cites W2035949829 @default.
- W2745958223 cites W2037598426 @default.
- W2745958223 cites W2039652459 @default.
- W2745958223 cites W2042094945 @default.
- W2745958223 cites W2042260470 @default.
- W2745958223 cites W2044575956 @default.
- W2745958223 cites W2047413151 @default.
- W2745958223 cites W2049672154 @default.
- W2745958223 cites W2049992843 @default.
- W2745958223 cites W2050031113 @default.
- W2745958223 cites W2050494693 @default.
- W2745958223 cites W2051909115 @default.
- W2745958223 cites W2052418593 @default.
- W2745958223 cites W2053352622 @default.
- W2745958223 cites W2055986307 @default.
- W2745958223 cites W2056433467 @default.
- W2745958223 cites W2060590248 @default.
- W2745958223 cites W2060643552 @default.
- W2745958223 cites W2061541169 @default.
- W2745958223 cites W2065197926 @default.
- W2745958223 cites W2065499345 @default.
- W2745958223 cites W2065505889 @default.
- W2745958223 cites W2065653828 @default.
- W2745958223 cites W2065759372 @default.
- W2745958223 cites W2066797135 @default.