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- W2745970345 endingPage "27" @default.
- W2745970345 startingPage "15" @default.
- W2745970345 abstract "Binge-eating disorder (BED) is the most prevalent eating disorder with estimates of 2–5% of the general adult population. Nonetheless, its pathophysiology is poorly understood. Furthermore, there exist few therapeutic options for its effective treatment. Here we review the current state of binge-eating neurobiology and pharmacology, drawing from clinical therapeutic, neuroimaging, cognitive, human genetic and animal model studies. These studies, which are still in their infancy, indicate that while there are many gaps in our knowledge, several key neural substrates appear to underpin binge-eating and may be conserved between human and animals. This observation suggests that behavioral intermediate phenotypes or endophenotypes relevant to BED may be modeled in animals, facilitating the identification and testing of novel pharmacological targets. The development of novel, safe and effective pharmacological therapies for the treatment of BED will enhance the ability of clinicians to provide optimal care for people with BED." @default.
- W2745970345 created "2017-08-31" @default.
- W2745970345 creator A5066876280 @default.
- W2745970345 creator A5067499997 @default.
- W2745970345 creator A5085278505 @default.
- W2745970345 date "2018-02-01" @default.
- W2745970345 modified "2023-09-26" @default.
- W2745970345 title "Binge-eating disorder: Clinical and therapeutic advances" @default.
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