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• W2746014579 endingPage "52" @default.
• W2746014579 startingPage "43" @default.
• W2746014579 abstract "Cholera toxin B subunit fusion to autoantigens such as proinsulin (CTB-INS) down regulate dendritic cell (DC) activation and stimulate synthesis of DC immunosuppressive cytokines. Recent studies of CTB-INS induction of immune tolerance in human DCs indicate that increased biosynthesis of indoleamine 2,3-dioxygenase (IDO1) may play an important role in CTB-INS vaccine suppression of DC activation. Studies in murine models suggest a role for transforming growth factor beta (TGF-β) in the stimulation of IDO1 biosynthesis, for the induction of tolerance in DCs. Here, we investigated the contribution of TGF-β superfamily proteins to CTB-INS induction of IDO1 biosynthesis in human monocyte-derived DCs (moDCs). We show that CTB-INS upregulates the level of TGF-β1, activin-A and the TGF-β activator, integrin αvβ8 in human DCs. However, inhibition of endogenous TGF-β, activin-A or addition of biologically active TGF-β1, and activin-A, did not inhibit or stimulate IDO1 biosynthesis in human DCs treated with CTB-INS. While inhibition with the kinase inhibitor, RepSox, blocked SMAD2/3 phosphorylation and diminished IDO1 biosynthesis in a concentration dependent manner. Specific blocking of the TGF-β type 1 kinase receptor with SB-431542 did not arrest IDO1 biosynthesis, suggesting the involvement of a different kinase pathway other than TGF-β type 1 receptor kinase in CTB-INS induction of IDO1 in human moDCs. Together, our experimental findings identify additional immunoregulatory proteins induced by the CTB-INS fusion protein, suggesting CTB-INS may utilize multiple mechanisms in the induction of tolerance in human moDCs." @default.
• W2746014579 created "2017-08-31" @default.
• W2746014579 creator A5019694542 @default.
• W2746014579 creator A5075757369 @default.
• W2746014579 date "2017-09-01" @default.
• W2746014579 modified "2023-10-14" @default.
• W2746014579 title "Mechanism of chimeric vaccine stimulation of indoleamine 2,3-dioxygenase biosynthesis in human dendritic cells is independent of TGF-β signaling" @default.
• W2746014579 cites W1487018400 @default.
• W2746014579 cites W1495550348 @default.
• W2746014579 cites W1571546216 @default.
• W2746014579 cites W1582760249 @default.
• W2746014579 cites W1584463243 @default.
• W2746014579 cites W1590988658 @default.
• W2746014579 cites W1931073059 @default.
• W2746014579 cites W1963756724 @default.
• W2746014579 cites W1965781207 @default.
• W2746014579 cites W1968706116 @default.
• W2746014579 cites W1970098795 @default.
• W2746014579 cites W1973581994 @default.
• W2746014579 cites W1977708499 @default.
• W2746014579 cites W1978644292 @default.
• W2746014579 cites W1979784035 @default.
• W2746014579 cites W1984012411 @default.
• W2746014579 cites W1984214868 @default.
• W2746014579 cites W1987449859 @default.
• W2746014579 cites W1992686283 @default.
• W2746014579 cites W1994185723 @default.
• W2746014579 cites W2002015730 @default.
• W2746014579 cites W2007248734 @default.
• W2746014579 cites W2007316487 @default.
• W2746014579 cites W2010378562 @default.
• W2746014579 cites W2013445858 @default.
• W2746014579 cites W2025736353 @default.
• W2746014579 cites W2027860197 @default.
• W2746014579 cites W2034563022 @default.
• W2746014579 cites W2035653659 @default.
• W2746014579 cites W2036334866 @default.
• W2746014579 cites W2040114517 @default.
• W2746014579 cites W2044533205 @default.
• W2746014579 cites W2045341668 @default.
• W2746014579 cites W2047259732 @default.
• W2746014579 cites W2049423709 @default.
• W2746014579 cites W2052489836 @default.
• W2746014579 cites W2054311195 @default.
• W2746014579 cites W2057977337 @default.
• W2746014579 cites W2073243488 @default.
• W2746014579 cites W2079010923 @default.
• W2746014579 cites W2079766591 @default.
• W2746014579 cites W2081562224 @default.
• W2746014579 cites W2095946347 @default.
• W2746014579 cites W2096625946 @default.
• W2746014579 cites W2098984609 @default.
• W2746014579 cites W2103031848 @default.
• W2746014579 cites W2108806591 @default.
• W2746014579 cites W2113313714 @default.
• W2746014579 cites W2114269157 @default.
• W2746014579 cites W2114646110 @default.
• W2746014579 cites W2117814548 @default.
• W2746014579 cites W2121906940 @default.
• W2746014579 cites W2125061065 @default.
• W2746014579 cites W2126737730 @default.
• W2746014579 cites W2128589677 @default.
• W2746014579 cites W2133057473 @default.
• W2746014579 cites W2141860100 @default.
• W2746014579 cites W2146115265 @default.
• W2746014579 cites W2146457049 @default.
• W2746014579 cites W2147478452 @default.
• W2746014579 cites W2148567638 @default.
• W2746014579 cites W2148953720 @default.
• W2746014579 cites W2149755871 @default.
• W2746014579 cites W2151220680 @default.
• W2746014579 cites W2152857351 @default.
• W2746014579 cites W2155120317 @default.
• W2746014579 cites W2162946694 @default.
• W2746014579 cites W2170617867 @default.
• W2746014579 cites W2190444673 @default.
• W2746014579 cites W2190552151 @default.
• W2746014579 cites W2273939311 @default.
• W2746014579 cites W2300549741 @default.
• W2746014579 cites W2347012456 @default.
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• W2746014579 doi "https://doi.org/10.1016/j.cellimm.2017.08.002" @default.
• W2746014579 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28864263" @default.
• W2746014579 hasPublicationYear "2017" @default.
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