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- W2746128156 abstract "Hereditary hemochromatosis and iron imbalance are associated with susceptibility to bacterial infection; however, the underlying mechanisms are poorly understood. Here, we performed in vivo bacterial infection screening using several mouse models of hemochromatosis, including Hfe (Hfe-/- ), hemojuvelin (Hjv-/- ), and macrophage-specific ferroportin-1 (Fpn1fl/fl ;LysM-Cre+ ) knockout mice. We found that Hjv-/- mice, but not Hfe-/- or Fpn1fl/fl ;LysM-Cre+ mice, are highly susceptible to peritoneal infection by both Gram-negative and Gram-positive bacteria. Interestingly, phagocytic cells in the peritoneum of Hjv-/- mice have reduced bacterial clearance, IFN-γ secretion, and nitric oxide production; in contrast, both cell migration and phagocytosis are normal. Expressing Hjv in RAW264.7 cells increased the level of phosphorylated Stat1 and nitric oxide production. Moreover, macrophage-specific Hjv knockout mice are susceptible to bacterial infection. Finally, we found that Hjv facilitates the secretion of IFN-γ via the IL-12/Jak2/Stat4 signaling pathway. Together, these findings reveal a novel protective role of Hjv in the early stages of antimicrobial defense." @default.
- W2746128156 created "2017-08-31" @default.
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- W2746128156 date "2017-08-15" @default.
- W2746128156 modified "2023-10-16" @default.
- W2746128156 title "Hemojuvelin regulates the innate immune response to peritoneal bacterial infection in mice" @default.
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- W2746128156 cites W1579094233 @default.
- W2746128156 cites W1595293335 @default.
- W2746128156 cites W1658552097 @default.
- W2746128156 cites W1664175075 @default.
- W2746128156 cites W1768580582 @default.
- W2746128156 cites W1798797506 @default.
- W2746128156 cites W1888761419 @default.
- W2746128156 cites W1925210413 @default.
- W2746128156 cites W1977274516 @default.
- W2746128156 cites W1978008866 @default.
- W2746128156 cites W1979388939 @default.
- W2746128156 cites W1980613104 @default.
- W2746128156 cites W1990564189 @default.
- W2746128156 cites W1991109223 @default.
- W2746128156 cites W1997575279 @default.
- W2746128156 cites W2009795531 @default.
- W2746128156 cites W2009988274 @default.
- W2746128156 cites W2012836529 @default.
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- W2746128156 cites W2029441236 @default.
- W2746128156 cites W2030400155 @default.
- W2746128156 cites W2031283301 @default.
- W2746128156 cites W2032903020 @default.
- W2746128156 cites W2035189746 @default.
- W2746128156 cites W2050833520 @default.
- W2746128156 cites W2055111778 @default.
- W2746128156 cites W2063053561 @default.
- W2746128156 cites W2074692187 @default.
- W2746128156 cites W2075194248 @default.
- W2746128156 cites W2076102443 @default.
- W2746128156 cites W2076153232 @default.
- W2746128156 cites W2078956328 @default.
- W2746128156 cites W2079844680 @default.
- W2746128156 cites W2087334046 @default.
- W2746128156 cites W2089262366 @default.
- W2746128156 cites W2089836445 @default.
- W2746128156 cites W2091637866 @default.
- W2746128156 cites W2092095100 @default.
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- W2746128156 doi "https://doi.org/10.1038/celldisc.2017.28" @default.
- W2746128156 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5556331" @default.
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- W2746128156 hasPublicationYear "2017" @default.
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