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• W2746138134 abstract "// Wen-Feng Li 1, * , Yu-Qing Huang 1, * , Cheng Huang 1 and Ying-Qing Feng 1 1 Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China * These authors are contributed equally to this work Correspondence to: Cheng Huang, email: fyq1819@163.com Ying-Qing Feng, email: linfeng7822@sina.com Keywords: statins, chronic obstructive pulmonary disease, COPD, systematic review Received: June 16, 2017      Accepted: August 04, 2017      Published: August 17, 2017 ABSTRACT Recently, a number of observational studies have suggested that use of statins reduces mortality in patients suffering from chronic obstructive pulmonary disease (COPD). To obtain a more valid assessment, we update the meta-analysis of the effect of statins on COPD exacerbation and mortality. We searched for eligible articles using PubMed, Medline, Embase, the Cochrane Central Register of Controlled Trials, Cochrane Databases and Web of Science between January 2006 and February 2017, with no restrictions. The hazard ratio (HR) with 95% confidence interval (CI) was estimated. Publication bias was evaluated by funnel plot and Begg’s test. Sensitivity analyses were also conducted. Twenty studies with a total of 303,981 patients were included. Thirteen articles provided data on all-cause mortality (165,221 participants), and the pooled hazard ratio of 0.65 (95% CI: 0.57–0.74, P < 0.001). Nine cohorts involving 155,435 patients reported data for COPD exacerbation with or without hospitalization, and they gave a HR of 0.58(95%CI: 0.48–0.72, P < 0.001). Our systematic review of exclusively observational studies showed a clear benefit of statins for patients suffering from COPD." @default.
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• W2746138134 date "2017-08-17" @default.
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• W2746138134 title "Statins reduce all-cause mortality in chronic obstructive pulmonary disease: an updated systematic review and meta-analysis of observational studies" @default.
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• W2746138134 doi "https://doi.org/10.18632/oncotarget.20304" @default.
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