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• W2746196162 abstract "Mitochondria are organised as tubular networks in the cell and undergo fission and fusion. Equilibrium between fission and fusion events is necessary to maintain normal mitochondrial function. While several of the molecular players involved in mediating the dynamics of mitochondria have been identified, the precise cellular cues that initiate fission or fusion remain largely unknown. In fission yeast, as in mammalian cells, mitochondrial positioning and partitioning are microtubule-mediated. In interphase, fission yeast mitochondria associate with microtubule bundles that are aligned along the long axis of the cell. Here, we perturbed microtubule dynamics via kinesin-like proteins to produce cells with long and short microtubules and observed that cells with long microtubules exhibited long, but fewer mitochondria, whereas cells with short microtubules exhibited short, but several mitochondria. We quantified that mitochondrial fission frequency correlated inversely with microtubule length. In agreement with these results, upon onset of mitosis wherein interphase microtubules assemble to form the spindle within the nucleus, we measured increased fission of mitochondria in the absence of interphase microtubules. We confirmed that partitioning of mitochondria at mitosis follows a stochastic, independent segregation mechanism and that the increase in mitochondrial fission prior to cell division therefore likely serves to increase the likelihood of equal partitioning of mitochondria between the two future daughter cells. Further, association of mitochondria with microtubules inhibited activity of the dynamin GTPase-related fission protein Dnm1, such that cells overexpressing Dnm1 but containing long microtubules were protected from increased fission. Thus, we demonstrate a general mechanism by which mitochondrial dynamics is dictated by the dynamics of the microtubule cytoskeleton." @default.
• W2746196162 created "2017-08-31" @default.
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• W2746196162 date "2017-08-21" @default.
• W2746196162 modified "2023-09-26" @default.
• W2746196162 title "Microtubule dynamics regulates mitochondrial fission" @default.
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