FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2746240832> ?p ?o ?g. }

• W2746240832 endingPage "10093" @default.
• W2746240832 startingPage "10085" @default.
• W2746240832 abstract "Specific detection or imaging protein has high potential to contribute greatly to medical diagnosis, biological research, and therapeutic applications. The level of human serum albumin (HSA) in blood is related to a variety of diseases and thus serves as an important biomarker for fast clinical diagnosis. Here we report the use of aggregation-induced emission (AIE) based supramolecular assembly to design biomolecular responsive smart organic nanomaterials for detection protein HSA. The designed nanoprobes were aggregates of small molecules and silent in fluorescence, but in the presence of HSA they disassembled and produced a clear turn-on fluorescent signal. Of a small library of nanoprobes constructed for HSA detection, structure-optical signaling and screening studies revealed that nanoprobe 7 is the most efficient one. Mechanism studies showed that nanoprobe 7 was bonded with Site I of HSA through the multiple noncovalent interactions. The resultant restriction of intramolecular rotation of nanoprobe 7 in the hydrophobic cavity of HSA induced fluorescent emission, which was validated by competitive binding assays and molecular docking. More importantly, nanoprobe 7 was successfully applied to recognize and quantify HSA in human serum samples. This study demonstrates nanoprobe 7 is a promising tool for clinical real and fast detection of HSA and thus may find many applications, and the molecular assembly based on AIE also opens a new avenue for designing smart nanomaterials for the sensitive and selective detection for varied analytes." @default.
• W2746240832 created "2017-08-31" @default.
• W2746240832 creator A5001354020 @default.
• W2746240832 creator A5004795100 @default.
• W2746240832 creator A5011907617 @default.
• W2746240832 creator A5035900481 @default.
• W2746240832 creator A5066681489 @default.
• W2746240832 creator A5070403221 @default.
• W2746240832 creator A5075963891 @default.
• W2746240832 creator A5087114298 @default.
• W2746240832 date "2017-09-07" @default.
• W2746240832 modified "2023-10-14" @default.
• W2746240832 title "Smart Self-Assembled Organic Nanoprobe for Protein-Specific Detection: Design, Synthesis, Application, and Mechanism Studies" @default.
• W2746240832 cites W1967923624 @default.
• W2746240832 cites W1972147248 @default.
• W2746240832 cites W1973238993 @default.
• W2746240832 cites W1973387903 @default.
• W2746240832 cites W1975586699 @default.
• W2746240832 cites W1978059664 @default.
• W2746240832 cites W1978832930 @default.
• W2746240832 cites W1979973713 @default.
• W2746240832 cites W1984589199 @default.
• W2746240832 cites W1984701286 @default.
• W2746240832 cites W1991428014 @default.
• W2746240832 cites W1993282644 @default.
• W2746240832 cites W1993324025 @default.
• W2746240832 cites W2006957711 @default.
• W2746240832 cites W2010547635 @default.
• W2746240832 cites W2016401253 @default.
• W2746240832 cites W2016527136 @default.
• W2746240832 cites W2022650937 @default.
• W2746240832 cites W2026227022 @default.
• W2746240832 cites W2029847924 @default.
• W2746240832 cites W2047417119 @default.
• W2746240832 cites W2069750287 @default.
• W2746240832 cites W2131216948 @default.
• W2746240832 cites W2135076718 @default.
• W2746240832 cites W2156101232 @default.
• W2746240832 cites W2157043696 @default.
• W2746240832 cites W2165120552 @default.
• W2746240832 cites W2167237931 @default.
• W2746240832 cites W2169219179 @default.
• W2746240832 cites W2177058120 @default.
• W2746240832 cites W2179461561 @default.
• W2746240832 cites W2198939625 @default.
• W2746240832 cites W2217777432 @default.
• W2746240832 cites W2254001924 @default.
• W2746240832 cites W2268072921 @default.
• W2746240832 cites W2289885333 @default.
• W2746240832 cites W2290577485 @default.
• W2746240832 cites W2404967489 @default.
• W2746240832 cites W2411318484 @default.
• W2746240832 cites W2462502641 @default.
• W2746240832 cites W2473338154 @default.
• W2746240832 cites W2513618503 @default.
• W2746240832 cites W2525121833 @default.
• W2746240832 cites W4230350617 @default.
• W2746240832 cites W914506434 @default.
• W2746240832 cites W991876575 @default.
• W2746240832 doi "https://doi.org/10.1021/acs.analchem.7b02923" @default.
• W2746240832 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28828856" @default.
• W2746240832 hasPublicationYear "2017" @default.
• W2746240832 type Work @default.
• W2746240832 sameAs 2746240832 @default.
• W2746240832 citedByCount "48" @default.
• W2746240832 countsByYear W27462408322018 @default.
• W2746240832 countsByYear W27462408322019 @default.
• W2746240832 countsByYear W27462408322020 @default.
• W2746240832 countsByYear W27462408322021 @default.
• W2746240832 countsByYear W27462408322022 @default.
• W2746240832 countsByYear W27462408322023 @default.
• W2746240832 crossrefType "journal-article" @default.
• W2746240832 hasAuthorship W2746240832A5001354020 @default.
• W2746240832 hasAuthorship W2746240832A5004795100 @default.
• W2746240832 hasAuthorship W2746240832A5011907617 @default.
• W2746240832 hasAuthorship W2746240832A5035900481 @default.
• W2746240832 hasAuthorship W2746240832A5066681489 @default.
• W2746240832 hasAuthorship W2746240832A5070403221 @default.
• W2746240832 hasAuthorship W2746240832A5075963891 @default.
• W2746240832 hasAuthorship W2746240832A5087114298 @default.
• W2746240832 hasBestOaLocation W27462408322 @default.
• W2746240832 hasConcept C10390740 @default.
• W2746240832 hasConcept C121332964 @default.
• W2746240832 hasConcept C138631740 @default.
• W2746240832 hasConcept C155672457 @default.
• W2746240832 hasConcept C160756335 @default.
• W2746240832 hasConcept C16387964 @default.
• W2746240832 hasConcept C171250308 @default.
• W2746240832 hasConcept C185592680 @default.
• W2746240832 hasConcept C192562407 @default.
• W2746240832 hasConcept C2778597219 @default.
• W2746240832 hasConcept C43617362 @default.
• W2746240832 hasConcept C53105671 @default.
• W2746240832 hasConcept C55493867 @default.
• W2746240832 hasConcept C62520636 @default.
• W2746240832 hasConcept C91881484 @default.
• W2746240832 hasConceptScore W2746240832C10390740 @default.
• W2746240832 hasConceptScore W2746240832C121332964 @default.

• next