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- W2746276409 abstract "The blood brain barrier (BBB) protects the internal milieu of the central nervous system by barring entry of most serum proteins. Perturbation of the BBB occurs with many pathologic conditions and may have prognostic significance. BBB status may also influence diagnosis and treatment of brain injury by limiting the availability of brain specific proteins in the serum and the delivery of therapeutic agents to the central nervous system (CNS), respectively. This study evaluated two putative serum markers of BBB disruption in patients with clinically defined mild traumatic brain injury (mTBI). Monomeric transthyretin (TTR) is a CNS specific protein present in serum after osmotic disruption of the BBB while S100B is an astrocytic protein believed to be a marker of BBB integrity." @default.
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- W2746276409 date "2006-10-01" @default.
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- W2746276409 title "367" @default.
- W2746276409 doi "https://doi.org/10.1016/j.annemergmed.2006.07.833" @default.
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