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• W2746280574 startingPage "5530" @default.
• W2746280574 abstract "Abstract Sister chromatids are held together by cohesin, a tripartite ring with a peripheral SA1/2 subunit, where SA1 is required for telomere cohesion and SA2 for centromere cohesion. The STAG2 gene encoding SA2 is often inactivated in human cancer, but not in in a manner associated with aneuploidy. Thus, how these tumors maintain chromosomal cohesion and how STAG2 loss contributes to tumorigenesis remain open questions. Here we show that, despite a loss in centromere cohesion, sister chromatids in STAG2 mutant tumor cells maintain cohesion in mitosis at chromosome arms and telomeres. Telomere maintenance in STAG2 mutant tumor cells occurred by either telomere recombination or telomerase activation mechanisms. Notably, these cells were refractory to telomerase inhibitors, indicating recombination can provide an alternative means of telomere maintenance. STAG2 silencing in normal human cells that lack telomerase led to increased recombination at telomeres, delayed telomere shortening, and postponed senescence onset. Insofar as telomere shortening and replicative senescence prevent genomic instability and cancer by limiting the number of cell divisions, our findings suggest that extending the lifespan of normal human cells due to inactivation of STAG2 could promote tumorigenesis by extending the period during which tumor-driving mutations occur. Cancer Res; 77(20); 5530–42. ©2017 AACR." @default.
• W2746280574 created "2017-08-31" @default.
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• W2746280574 date "2017-10-15" @default.
• W2746280574 modified "2023-09-29" @default.
• W2746280574 title "Loss of Tumor Suppressor <i>STAG2</i> Promotes Telomere Recombination and Extends the Replicative Lifespan of Normal Human Cells" @default.
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• W2746280574 doi "https://doi.org/10.1158/0008-5472.can-17-1260" @default.
• W2746280574 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5645240" @default.
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