FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2746339871> ?p ?o ?g. }

• W2746339871 endingPage "10" @default.
• W2746339871 startingPage "1" @default.
• W2746339871 abstract "We examined the antiosteoarthritic effect of the n-hexane extract of Litsea japonica fruit flesh (LJF-HE) in a rat model of monosodium-iodoacetate- (MIA-) induced osteoarthritis. LJF-HE significantly reduced the difference in weight-bearing capabilities of the hind paws between healthy and MIA-treated rats. Histological examination of the knee joints indicated that LJF-HE suppressed cartilage and bone destruction. Additionally, there were decreases in the expression of matrix metalloproteinase-2 and metalloproteinase-9 and cyclooxygenase-2 in the joints. The serum levels of deoxypyridinoline (DPD) and osteocalcin, which are markers of bone metabolism, also decreased. Furthermore, LJF-HE significantly suppressed infiltration of inflammatory cells into the synovium and inhibited the expression of proinflammatory cytokines such as tumor necrosis factor- (TNF-) α , interleukin- (IL-) 1, and IL-6 in the joints and serum. The serum levels of leukotriene B4 and lipoxygenase were also significantly lowered by LJF-HE. Finally, LJF-HE inhibited the production of nitric oxide, prostaglandin E2, IL-6, and TNF- α in lipopolysaccharide-activated macrophages, which might be associated with inhibited phosphorylation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase. Our data suggest that LJF-HE has an anti-inflammatory effect and may have potential as an antiosteoarthritic agent." @default.
• W2746339871 created "2017-08-31" @default.
• W2746339871 creator A5018966008 @default.
• W2746339871 creator A5021528859 @default.
• W2746339871 creator A5025455826 @default.
• W2746339871 creator A5050743214 @default.
• W2746339871 creator A5054220148 @default.
• W2746339871 creator A5058713458 @default.
• W2746339871 creator A5060550819 @default.
• W2746339871 creator A5065308057 @default.
• W2746339871 creator A5065332557 @default.
• W2746339871 date "2017-01-01" @default.
• W2746339871 modified "2023-10-04" @default.
• W2746339871 title "Suppressive Effect of the n-Hexane Extract of<i> Litsea japonica</i> Fruit Flesh on Monosodium-Iodoacetate-Induced Osteoarthritis in Rats" @default.
• W2746339871 cites W1586814698 @default.
• W2746339871 cites W1924921707 @default.
• W2746339871 cites W1969122642 @default.
• W2746339871 cites W1976228547 @default.
• W2746339871 cites W1980855151 @default.
• W2746339871 cites W1984981145 @default.
• W2746339871 cites W1993990835 @default.
• W2746339871 cites W2010802338 @default.
• W2746339871 cites W2012660332 @default.
• W2746339871 cites W2014247135 @default.
• W2746339871 cites W2017869529 @default.
• W2746339871 cites W2023454848 @default.
• W2746339871 cites W2026742987 @default.
• W2746339871 cites W2033701197 @default.
• W2746339871 cites W2033892914 @default.
• W2746339871 cites W2057491978 @default.
• W2746339871 cites W2068864388 @default.
• W2746339871 cites W2073512971 @default.
• W2746339871 cites W2076816724 @default.
• W2746339871 cites W2084386397 @default.
• W2746339871 cites W2096525876 @default.
• W2746339871 cites W2115899272 @default.
• W2746339871 cites W2144428814 @default.
• W2746339871 cites W2149601524 @default.
• W2746339871 cites W2291181079 @default.
• W2746339871 doi "https://doi.org/10.1155/2017/1791403" @default.
• W2746339871 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5585680" @default.
• W2746339871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28904551" @default.
• W2746339871 hasPublicationYear "2017" @default.
• W2746339871 type Work @default.
• W2746339871 sameAs 2746339871 @default.
• W2746339871 citedByCount "8" @default.
• W2746339871 countsByYear W27463398712018 @default.
• W2746339871 countsByYear W27463398712019 @default.
• W2746339871 countsByYear W27463398712020 @default.
• W2746339871 countsByYear W27463398712022 @default.
• W2746339871 countsByYear W27463398712023 @default.
• W2746339871 crossrefType "journal-article" @default.
• W2746339871 hasAuthorship W2746339871A5018966008 @default.
• W2746339871 hasAuthorship W2746339871A5021528859 @default.
• W2746339871 hasAuthorship W2746339871A5025455826 @default.
• W2746339871 hasAuthorship W2746339871A5050743214 @default.
• W2746339871 hasAuthorship W2746339871A5054220148 @default.
• W2746339871 hasAuthorship W2746339871A5058713458 @default.
• W2746339871 hasAuthorship W2746339871A5060550819 @default.
• W2746339871 hasAuthorship W2746339871A5065308057 @default.
• W2746339871 hasAuthorship W2746339871A5065332557 @default.
• W2746339871 hasBestOaLocation W27463398711 @default.
• W2746339871 hasConcept C126322002 @default.
• W2746339871 hasConcept C134018914 @default.
• W2746339871 hasConcept C142724271 @default.
• W2746339871 hasConcept C164027704 @default.
• W2746339871 hasConcept C17991360 @default.
• W2746339871 hasConcept C184235292 @default.
• W2746339871 hasConcept C185592680 @default.
• W2746339871 hasConcept C204787440 @default.
• W2746339871 hasConcept C2776164576 @default.
• W2746339871 hasConcept C2776914184 @default.
• W2746339871 hasConcept C2777956040 @default.
• W2746339871 hasConcept C2778690821 @default.
• W2746339871 hasConcept C519581460 @default.
• W2746339871 hasConcept C55493867 @default.
• W2746339871 hasConcept C71924100 @default.
• W2746339871 hasConcept C74172505 @default.
• W2746339871 hasConceptScore W2746339871C126322002 @default.
• W2746339871 hasConceptScore W2746339871C134018914 @default.
• W2746339871 hasConceptScore W2746339871C142724271 @default.
• W2746339871 hasConceptScore W2746339871C164027704 @default.
• W2746339871 hasConceptScore W2746339871C17991360 @default.
• W2746339871 hasConceptScore W2746339871C184235292 @default.
• W2746339871 hasConceptScore W2746339871C185592680 @default.
• W2746339871 hasConceptScore W2746339871C204787440 @default.
• W2746339871 hasConceptScore W2746339871C2776164576 @default.
• W2746339871 hasConceptScore W2746339871C2776914184 @default.
• W2746339871 hasConceptScore W2746339871C2777956040 @default.
• W2746339871 hasConceptScore W2746339871C2778690821 @default.
• W2746339871 hasConceptScore W2746339871C519581460 @default.
• W2746339871 hasConceptScore W2746339871C55493867 @default.
• W2746339871 hasConceptScore W2746339871C71924100 @default.
• W2746339871 hasConceptScore W2746339871C74172505 @default.
• W2746339871 hasFunder F4320322033 @default.
• W2746339871 hasLocation W27463398711 @default.
• W2746339871 hasLocation W27463398712 @default.
• W2746339871 hasLocation W27463398713 @default.

• next