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- W2746366920 abstract "Abstract TRAIL is a promising anticancer agent due to its unique ability to kill tumor cells selectively without harming non-malignant cells. However, some cancer cells are reported to be TRAIL - resistant. Searching potent TRAIL agonist to overcome resistance is an important strategy for its successful use as an anticancer agent. As a part of our continuous research on natural inhibitors, activity-guided fractionation of the MeOH extract of Boesenbergia pandurata rhizomes afforded three ( 1 – 3 ) new isopimarane diterpenes, boesenberols I–K, together with two ( 4 – 5 ) known compounds. The structures of these new compounds were elucidated using HRESIMS, IR, 1D and 2D NMR spectroscopy. All compounds showed TRAIL-resistance overcoming activity." @default.
- W2746366920 created "2017-08-31" @default.
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- W2746366920 date "2017-10-01" @default.
- W2746366920 modified "2023-09-24" @default.
- W2746366920 title "Boesenberols I–K, new isopimarane diterpenes from Boesenbergia pandurata with TRAIL-resistance overcoming activity" @default.
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- W2746366920 doi "https://doi.org/10.1016/j.tetlet.2017.08.055" @default.
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