FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2746438609> ?p ?o ?g. }

• W2746438609 endingPage "1880" @default.
• W2746438609 startingPage "1867" @default.
• W2746438609 abstract "The NMDA receptor (NMDAR) antagonist ketamine elicits a long-lasting antidepressant response in patients with treatment-resistant depression. Understanding how antagonism of NMDARs alters synapse and circuit function is pivotal to developing circuit-based therapies for depression. Using virally induced gene deletion, ex vivo optogenetic-assisted circuit analysis, and in vivo chemogenetics and fMRI, we assessed the role of NMDARs in the medial prefrontal cortex (mPFC) in controlling depression-related behavior in mice. We demonstrate that post-developmental genetic deletion of the NMDAR subunit GluN2B from pyramidal neurons in the mPFC enhances connectivity between the mPFC and limbic thalamus, but not the ventral hippocampus, and reduces depression-like behavior. Using intersectional chemogenetics, we show that activation of this thalamocortical circuit is sufficient to elicit a decrease in despair-like behavior. Our findings reveal that GluN2B exerts input-specific control of pyramidal neuron innervation and identify a medial dorsal thalamus (MDT)→mPFC circuit that controls depression-like behavior." @default.
• W2746438609 created "2017-08-31" @default.
• W2746438609 creator A5000806902 @default.
• W2746438609 creator A5007587443 @default.
• W2746438609 creator A5021685997 @default.
• W2746438609 creator A5056022403 @default.
• W2746438609 creator A5087023478 @default.
• W2746438609 date "2017-08-01" @default.
• W2746438609 modified "2023-10-16" @default.
• W2746438609 title "Synaptic Regulation of a Thalamocortical Circuit Controls Depression-Related Behavior" @default.
• W2746438609 cites W106141043 @default.
• W2746438609 cites W1608242764 @default.
• W2746438609 cites W1770278459 @default.
• W2746438609 cites W1812482953 @default.
• W2746438609 cites W1969635562 @default.
• W2746438609 cites W1970720793 @default.
• W2746438609 cites W1972742113 @default.
• W2746438609 cites W1976392245 @default.
• W2746438609 cites W1977514547 @default.
• W2746438609 cites W1979420282 @default.
• W2746438609 cites W1981517627 @default.
• W2746438609 cites W1981524444 @default.
• W2746438609 cites W1983784678 @default.
• W2746438609 cites W1985640311 @default.
• W2746438609 cites W1985661446 @default.
• W2746438609 cites W1988244113 @default.
• W2746438609 cites W1989045560 @default.
• W2746438609 cites W1993465148 @default.
• W2746438609 cites W2004762037 @default.
• W2746438609 cites W2005559664 @default.
• W2746438609 cites W2009509151 @default.
• W2746438609 cites W2009797032 @default.
• W2746438609 cites W2010931822 @default.
• W2746438609 cites W2012579750 @default.
• W2746438609 cites W2016334402 @default.
• W2746438609 cites W2022732040 @default.
• W2746438609 cites W2023156590 @default.
• W2746438609 cites W2023595618 @default.
• W2746438609 cites W2024640553 @default.
• W2746438609 cites W2025204726 @default.
• W2746438609 cites W2026147918 @default.
• W2746438609 cites W2035235513 @default.
• W2746438609 cites W2035346633 @default.
• W2746438609 cites W2040330981 @default.
• W2746438609 cites W2042404539 @default.
• W2746438609 cites W2047180856 @default.
• W2746438609 cites W2047397795 @default.
• W2746438609 cites W2051005796 @default.
• W2746438609 cites W2057704927 @default.
• W2746438609 cites W2058082904 @default.
• W2746438609 cites W2058867280 @default.
• W2746438609 cites W2060616948 @default.
• W2746438609 cites W2063783720 @default.
• W2746438609 cites W2069281265 @default.
• W2746438609 cites W2070475355 @default.
• W2746438609 cites W2070915934 @default.
• W2746438609 cites W2071815275 @default.
• W2746438609 cites W2072296702 @default.
• W2746438609 cites W2079590230 @default.
• W2746438609 cites W2086305648 @default.
• W2746438609 cites W2088177395 @default.
• W2746438609 cites W2088358935 @default.
• W2746438609 cites W2089299823 @default.
• W2746438609 cites W2090664493 @default.
• W2746438609 cites W2090737759 @default.
• W2746438609 cites W2095110547 @default.
• W2746438609 cites W2096093149 @default.
• W2746438609 cites W2097241494 @default.
• W2746438609 cites W2100172760 @default.
• W2746438609 cites W2100804779 @default.
• W2746438609 cites W2102918908 @default.
• W2746438609 cites W2104135721 @default.
• W2746438609 cites W2109334244 @default.
• W2746438609 cites W2111247524 @default.
• W2746438609 cites W2114104729 @default.
• W2746438609 cites W2123517430 @default.
• W2746438609 cites W2127958931 @default.
• W2746438609 cites W2128346152 @default.
• W2746438609 cites W2132969335 @default.
• W2746438609 cites W2139970636 @default.
• W2746438609 cites W2143999471 @default.
• W2746438609 cites W2144299211 @default.
• W2746438609 cites W2151488696 @default.
• W2746438609 cites W2158022157 @default.
• W2746438609 cites W2161201932 @default.
• W2746438609 cites W2161234653 @default.
• W2746438609 cites W2168927779 @default.
• W2746438609 cites W2172294131 @default.
• W2746438609 cites W2200324439 @default.
• W2746438609 cites W2203568037 @default.
• W2746438609 cites W2206080083 @default.
• W2746438609 cites W2236139809 @default.
• W2746438609 cites W2254443919 @default.
• W2746438609 cites W2340439758 @default.
• W2746438609 cites W2505475551 @default.
• W2746438609 cites W2507495628 @default.
• W2746438609 cites W2517085860 @default.
• W2746438609 cites W2566853258 @default.

• next