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- W2746481294 abstract "Artemisinin is an anti-malarial drug with poor water solubility and oral absorption; so a variety of derivatives based on the parent nucleus have been developed. Compared with artemisinin, dihydroartemisinin (DHA) has a stronger anti-malaria activity, and has the advantages of high metabolic rate and better water solubility. Recent studies have discovered that DHA has a good inhibitory effect on tumor cells, which is closely related to the peroxide bridge in its molecular structure. Since tumor cells need more Fe3+ than normal cells, there are a large number of transferrin receptors on the tumor cell membrane. DHA can break the peroxide bridge in the presence of Fe2+, and the free radicals generated can play its lethal effect on tumor cells. In addition, DHA can promote endocytosis of transferrin receptor, and thus prevent cancer cells from taking Fe3+ from microenvironment. This article reviews the anti-tumor molecular mechanism of DHA, including accelerating oxidative damage, inducing apoptosis, inhibiting the growth, proliferation and invasion of tumor cells, reversing tumor multidrug resistance." @default.
- W2746481294 created "2017-08-31" @default.
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- W2746481294 date "2016-05-25" @default.
- W2746481294 modified "2023-10-16" @default.
- W2746481294 title "[Progress on anti-tumor molecular mechanisms of dihydroartemisinin]." @default.
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- W2746481294 doi "https://doi.org/10.3785/j.issn.1008-9292.2016.09.08" @default.
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