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- W2746503755 abstract "Agmatine, decarboxylated arginine, is an NMDA receptor (NMDAr) antagonist, nitric oxide synthase (NOS) inhibitor and putative neuromodulator. NMDAr and NOS inhibitors are known to prevent opioid tolerance and self-administration; it has been previously reported that the development of morphine tolerance and fentanyl self-administration is reduced by systemic agmatine injection. However, it is assumed that the site(s) of agmatine action is in the central nervous system. Our group previously identified a CNS site of action by showing that intrathecally administered agmatine prevents morphine spinal tolerance and well as hyperalgesia in neuropathic and inflammatory pain models." @default.
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- W2746503755 date "2007-04-01" @default.
- W2746503755 modified "2023-09-23" @default.
- W2746503755 title "(661)" @default.
- W2746503755 doi "https://doi.org/10.1016/j.jpain.2007.02.072" @default.
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