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- W2746504620 abstract "Background: Despite the introduction of new antiepileptic drugs (AEDs), the quality of life and therapeutic response for patients with epilepsy remain unsatisfactory. In addition, whilst several antiepileptic drugs (AEDs) have been approved and consequently marketed in recent years, little is known about their long-term safety and tolerability. Availability of the newest AEDs, characterized by improved pharmacokinetic profiles, has positively impacted the treatment approach for patients with partial seizures in clinical practice. However, the main cause of treatment failure is still poor patient compliance due to the occurrence of adverse drug reactions (ADRs) that lead to treatment withdrawal in about 25% of cases before achieving maximal efficacy, and is associated with increasing health care costs. Keywords: Antiepileptic drugs, adverse drug reactions, tolerability, safety, interactions, clinical trials, metanalysis, pooled analysis." @default.
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- W2746504620 date "2018-02-09" @default.
- W2746504620 modified "2023-10-15" @default.
- W2746504620 title "Safety Profile of the Newest Antiepileptic Drugs: A Curated Literature Review" @default.
- W2746504620 doi "https://doi.org/10.2174/1381612823666170809115429" @default.
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