FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2746531389> ?p ?o ?g. }

• W2746531389 endingPage "1695" @default.
• W2746531389 startingPage "1686" @default.
• W2746531389 abstract "Ischemic stroke is a leading cause of death and disability worldwide, and autophagy may be involved in the pathological process of cerebral ischemia/reperfusion injury. Hydrogen sulfide (H2S) is an endogenous gasotransmitter with protective effects against multiple diseases. Here, we tested the effect of H2S on cerebral ischemia/reperfusion injury in rats. Sodium hydrosulfide (NaHS), an H2S donor, improved neurological function and reduced the size of the infarcts induced by transient middle cerebral artery occlusion (MCAO) followed by reperfusion in rats. NaHS treatment reduced the lactate dehydrogenase (LDH) activity in the serum (a marker of cellular membrane integrity) and the expression of cleaved caspase-3 (a marker for apoptosis) in the brains of MCAO rats. We also found that autophagy was overactivated in the brains of MCAO rats, as indicated by an increased ratio of LC3 II to I, decreased expression of p62, and transmission electron microscope detection. NaHS treatment significantly inhibited the autophagic activity in the brains of MCAO rats. Furthermore, PC12 cells were subjected to oxygen-glucose deprivation/reoxygenation (OGD/R) to mimic MCAO in vitro. We found that NaHS treatment reduced cellular injury and suppressed overactivated autophagy induced by OGD/R in PC12 cells. An autophagy stimulator (rapamycin) eliminated the protective effect of NaHS against LDH release and caspase-3 activity induced by OGD/R in PC12 cells. An autophagy inhibitor (3-methyladenine, 3-MA) also reduced the cellular injury induced by OGD/R in PC12 cells. In conclusion, the results indicate that overactivated autophagy accelerates cellular injury after MCAO in rats and that exogenous H2S attenuates cerebral ischemia/reperfusion injury via suppressing overactivated autophagy in rats." @default.
• W2746531389 created "2017-08-31" @default.
• W2746531389 creator A5007321516 @default.
• W2746531389 creator A5010415228 @default.
• W2746531389 creator A5033629870 @default.
• W2746531389 creator A5040776965 @default.
• W2746531389 creator A5067749727 @default.
• W2746531389 date "2017-09-21" @default.
• W2746531389 modified "2023-10-01" @default.
• W2746531389 title "Sodium hydrosulfide attenuates cerebral ischemia/reperfusion injury by suppressing overactivated autophagy in rats" @default.
• W2746531389 cites W1747150305 @default.
• W2746531389 cites W1888923685 @default.
• W2746531389 cites W2001741720 @default.
• W2746531389 cites W2022123660 @default.
• W2746531389 cites W2025024445 @default.
• W2746531389 cites W2032578573 @default.
• W2746531389 cites W2044553450 @default.
• W2746531389 cites W2046297960 @default.
• W2746531389 cites W2049065271 @default.
• W2746531389 cites W2074435305 @default.
• W2746531389 cites W2080981205 @default.
• W2746531389 cites W2100166573 @default.
• W2746531389 cites W2107446848 @default.
• W2746531389 cites W2150950241 @default.
• W2746531389 cites W2225379276 @default.
• W2746531389 cites W2231256722 @default.
• W2746531389 cites W2290984819 @default.
• W2746531389 cites W2312765121 @default.
• W2746531389 cites W2338692997 @default.
• W2746531389 cites W2401425325 @default.
• W2746531389 cites W2409292868 @default.
• W2746531389 cites W2415075823 @default.
• W2746531389 cites W2461453575 @default.
• W2746531389 cites W2462958992 @default.
• W2746531389 cites W2466930932 @default.
• W2746531389 cites W2469560829 @default.
• W2746531389 cites W2494396943 @default.
• W2746531389 cites W2518648107 @default.
• W2746531389 cites W2530455452 @default.
• W2746531389 cites W2536128271 @default.
• W2746531389 cites W2546905994 @default.
• W2746531389 cites W2553361440 @default.
• W2746531389 doi "https://doi.org/10.1002/2211-5463.12301" @default.
• W2746531389 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5666398" @default.
• W2746531389 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29123977" @default.
• W2746531389 hasPublicationYear "2017" @default.
• W2746531389 type Work @default.
• W2746531389 sameAs 2746531389 @default.
• W2746531389 citedByCount "53" @default.
• W2746531389 countsByYear W27465313892018 @default.
• W2746531389 countsByYear W27465313892019 @default.
• W2746531389 countsByYear W27465313892020 @default.
• W2746531389 countsByYear W27465313892021 @default.
• W2746531389 countsByYear W27465313892022 @default.
• W2746531389 countsByYear W27465313892023 @default.
• W2746531389 crossrefType "journal-article" @default.
• W2746531389 hasAuthorship W2746531389A5007321516 @default.
• W2746531389 hasAuthorship W2746531389A5010415228 @default.
• W2746531389 hasAuthorship W2746531389A5033629870 @default.
• W2746531389 hasAuthorship W2746531389A5040776965 @default.
• W2746531389 hasAuthorship W2746531389A5067749727 @default.
• W2746531389 hasBestOaLocation W27465313891 @default.
• W2746531389 hasConcept C126322002 @default.
• W2746531389 hasConcept C16613235 @default.
• W2746531389 hasConcept C178790620 @default.
• W2746531389 hasConcept C181199279 @default.
• W2746531389 hasConcept C185592680 @default.
• W2746531389 hasConcept C190283241 @default.
• W2746531389 hasConcept C203522944 @default.
• W2746531389 hasConcept C2777318727 @default.
• W2746531389 hasConcept C2780114680 @default.
• W2746531389 hasConcept C2780519940 @default.
• W2746531389 hasConcept C2780564542 @default.
• W2746531389 hasConcept C42219234 @default.
• W2746531389 hasConcept C518881349 @default.
• W2746531389 hasConcept C541997718 @default.
• W2746531389 hasConcept C55493867 @default.
• W2746531389 hasConcept C71924100 @default.
• W2746531389 hasConcept C98274493 @default.
• W2746531389 hasConceptScore W2746531389C126322002 @default.
• W2746531389 hasConceptScore W2746531389C16613235 @default.
• W2746531389 hasConceptScore W2746531389C178790620 @default.
• W2746531389 hasConceptScore W2746531389C181199279 @default.
• W2746531389 hasConceptScore W2746531389C185592680 @default.
• W2746531389 hasConceptScore W2746531389C190283241 @default.
• W2746531389 hasConceptScore W2746531389C203522944 @default.
• W2746531389 hasConceptScore W2746531389C2777318727 @default.
• W2746531389 hasConceptScore W2746531389C2780114680 @default.
• W2746531389 hasConceptScore W2746531389C2780519940 @default.
• W2746531389 hasConceptScore W2746531389C2780564542 @default.
• W2746531389 hasConceptScore W2746531389C42219234 @default.
• W2746531389 hasConceptScore W2746531389C518881349 @default.
• W2746531389 hasConceptScore W2746531389C541997718 @default.
• W2746531389 hasConceptScore W2746531389C55493867 @default.
• W2746531389 hasConceptScore W2746531389C71924100 @default.
• W2746531389 hasConceptScore W2746531389C98274493 @default.
• W2746531389 hasFunder F4320321001 @default.
• W2746531389 hasIssue "11" @default.

• next