FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W27465963> ?p ?o ?g. }

• W27465963 abstract "From seeds of Arctium lappa L. (Asteraceae) we obtained arctigenin (1), arctiin (2), chlorogenic acid (3), 4,5-dicaffeoylquinic acid (4), 3,5-dicaffeoylquinic acid (5), 3,4-dicaffeoylquinic acid (6), matairesinol (11), isolappaol A (12), lappaol F (14), and lappaol B (15), together with 1:1 mixtures of isolappaol C (7) and lappaol C (8), arctignan E (9) and arctignan D (10), and 12 and lappaol A (13), while 3,3′,4′-tri- O-demethylarctigenin (16), 3,3′-di- O-demethyl-4′-dehydroxyarctigenin (17), and 3- O-demethylarctigenin (18) were obtained by anaerobic microbiological metabolism of 1. Then, we evaluated the in vitro preferential cytotoxic activity of these pure compounds and 1:1 mixtures, together with enterodiol (19) and enterolactone (20), against human pancreatic cancer PANC-1 cells in nutrient-deprived medium (NDM). Among them, 1 and 18 showed potent activity, with PC 50 values of 1.75 and 4.38 μ M, respectively, while 11, 15, and 17 showed mild activity with PC 50 values of 31.1, 30.9, and 38.7 μ/M, respectively. By comparing their structures and PC 50 values, the following structural moieties could be concluded to be important for the preferential cytotoxicity of 1: 1) the 3-hydroxy-4-methoxyphenyl group at the 2-position on the γ-butyrolactone ring, 2) the less polar substituent at the 3-position on the γ-butyrolactone ring, and 3) the γ-butyrolactone ring." @default.
• W27465963 created "2016-06-24" @default.
• W27465963 creator A5003548603 @default.
• W27465963 creator A5025631052 @default.
• W27465963 creator A5050748274 @default.
• W27465963 creator A5062232507 @default.
• W27465963 creator A5075603830 @default.
• W27465963 creator A5081347827 @default.
• W27465963 date "2013-04-01" @default.
• W27465963 modified "2023-09-25" @default.
• W27465963 title "Anti-austeric Activity of Phenolic Constituents of Seeds of Arctium lappa" @default.
• W27465963 cites W1426177467 @default.
• W27465963 cites W1552827566 @default.
• W27465963 cites W1963531920 @default.
• W27465963 cites W1968162861 @default.
• W27465963 cites W2015421371 @default.
• W27465963 cites W2030131498 @default.
• W27465963 cites W2038564633 @default.
• W27465963 cites W2040747249 @default.
• W27465963 cites W2042317840 @default.
• W27465963 cites W2063211465 @default.
• W27465963 cites W2067449160 @default.
• W27465963 cites W2092651802 @default.
• W27465963 cites W2093059734 @default.
• W27465963 cites W2118838802 @default.
• W27465963 cites W2122312251 @default.
• W27465963 cites W2135664875 @default.
• W27465963 cites W2139466117 @default.
• W27465963 cites W4247785462 @default.
• W27465963 doi "https://doi.org/10.1177/1934578x1300800414" @default.
• W27465963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23738454" @default.
• W27465963 hasPublicationYear "2013" @default.
• W27465963 type Work @default.
• W27465963 sameAs 27465963 @default.
• W27465963 citedByCount "10" @default.
• W27465963 countsByYear W274659632013 @default.
• W27465963 countsByYear W274659632014 @default.
• W27465963 countsByYear W274659632015 @default.
• W27465963 countsByYear W274659632019 @default.
• W27465963 countsByYear W274659632021 @default.
• W27465963 countsByYear W274659632022 @default.
• W27465963 crossrefType "journal-article" @default.
• W27465963 hasAuthorship W27465963A5003548603 @default.
• W27465963 hasAuthorship W27465963A5025631052 @default.
• W27465963 hasAuthorship W27465963A5050748274 @default.
• W27465963 hasAuthorship W27465963A5062232507 @default.
• W27465963 hasAuthorship W27465963A5075603830 @default.
• W27465963 hasAuthorship W27465963A5081347827 @default.
• W27465963 hasBestOaLocation W274659631 @default.
• W27465963 hasConcept C109316439 @default.
• W27465963 hasConcept C185592680 @default.
• W27465963 hasConcept C202751555 @default.
• W27465963 hasConcept C2777164284 @default.
• W27465963 hasConcept C2777927066 @default.
• W27465963 hasConcept C2778270713 @default.
• W27465963 hasConcept C2778689049 @default.
• W27465963 hasConcept C2779878721 @default.
• W27465963 hasConcept C2780117898 @default.
• W27465963 hasConcept C2909562583 @default.
• W27465963 hasConcept C31903555 @default.
• W27465963 hasConcept C54355233 @default.
• W27465963 hasConcept C55493867 @default.
• W27465963 hasConcept C556039675 @default.
• W27465963 hasConcept C59822182 @default.
• W27465963 hasConcept C71240020 @default.
• W27465963 hasConcept C71924100 @default.
• W27465963 hasConcept C86803240 @default.
• W27465963 hasConceptScore W27465963C109316439 @default.
• W27465963 hasConceptScore W27465963C185592680 @default.
• W27465963 hasConceptScore W27465963C202751555 @default.
• W27465963 hasConceptScore W27465963C2777164284 @default.
• W27465963 hasConceptScore W27465963C2777927066 @default.
• W27465963 hasConceptScore W27465963C2778270713 @default.
• W27465963 hasConceptScore W27465963C2778689049 @default.
• W27465963 hasConceptScore W27465963C2779878721 @default.
• W27465963 hasConceptScore W27465963C2780117898 @default.
• W27465963 hasConceptScore W27465963C2909562583 @default.
• W27465963 hasConceptScore W27465963C31903555 @default.
• W27465963 hasConceptScore W27465963C54355233 @default.
• W27465963 hasConceptScore W27465963C55493867 @default.
• W27465963 hasConceptScore W27465963C556039675 @default.
• W27465963 hasConceptScore W27465963C59822182 @default.
• W27465963 hasConceptScore W27465963C71240020 @default.
• W27465963 hasConceptScore W27465963C71924100 @default.
• W27465963 hasConceptScore W27465963C86803240 @default.
• W27465963 hasLocation W274659631 @default.
• W27465963 hasLocation W274659632 @default.
• W27465963 hasOpenAccess W27465963 @default.
• W27465963 hasPrimaryLocation W274659631 @default.
• W27465963 hasRelatedWork W1966778226 @default.
• W27465963 hasRelatedWork W1975136951 @default.
• W27465963 hasRelatedWork W1999100183 @default.
• W27465963 hasRelatedWork W2011847636 @default.
• W27465963 hasRelatedWork W2024166789 @default.
• W27465963 hasRelatedWork W2052126027 @default.
• W27465963 hasRelatedWork W2054694964 @default.
• W27465963 hasRelatedWork W2058704386 @default.
• W27465963 hasRelatedWork W2076596080 @default.
• W27465963 hasRelatedWork W2085392063 @default.
• W27465963 hasRelatedWork W2092419031 @default.

• next