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• W2746702938 startingPage "33" @default.
• W2746702938 abstract "Leptospirosis causes severe clinical signs more frequently in men than in women, but the mechanism underlying the gender differences in leptospirosis remains unclear. In this study, petechial hemorrhage was observed in male but not in female hamster lung tissues infected with Leptospira interrogans serovar Hebdomadis at 120 h pi, demonstrating that male hamsters were more susceptible to the development of a severe disease upon Leptospira infection. No leptospiral DNA was detected in the lung tissues at 120 h pi when pulmonary hemorrhage was observed, indicating that pulmonary hemorrhage is attributable to the immune reactions of the host rather than from the direct effect of leptospires. The upregulation of nitric oxide synthase genes in the hamsters without pulmonary hemorrhage, inos and enos in female hamsters at 96 h pi and enos in male animals without hemorrhage at 120 h pi, may suggest that nitric oxide has a suppressive effect on leptospirosis-associated pulmonary hemorrhage." @default.
• W2746702938 created "2017-08-31" @default.
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• W2746702938 date "2017-10-01" @default.
• W2746702938 modified "2023-10-10" @default.
• W2746702938 title "Male-specific pulmonary hemorrhage and cytokine gene expression in golden hamster in early-phase Leptospira interrogans serovar Hebdomadis infection" @default.
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• W2746702938 doi "https://doi.org/10.1016/j.micpath.2017.08.016" @default.
• W2746702938 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28811249" @default.
• W2746702938 hasPublicationYear "2017" @default.
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