FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2746710740> ?p ?o ?g. }

• W2746710740 abstract "Patients with liver cirrhosis can develop hyperammonemia and hepatic encephalopathy (HE), accompanied by pronounced daytime sleepiness. Previous studies with healthy volunteers show that experimental increase in blood ammonium levels increases sleepiness and slows the waking EEG. As ammonium increases adenosine levels in vitro, and adenosine is a known regulator of sleep/wake homeostasis, we hypothesized that the sleepiness-inducing effect of ammonium is mediated by adenosine. Eight adult male Wistar rats were fed with an ammonium-enriched diet for 4 weeks; eight rats on standard diet served as controls. Each animal was implanted with electroencephalography/electromyography (EEG/EMG) electrodes and a microdialysis probe. Sleep EEG recording and cerebral microdialysis were carried out at baseline and after 6 hours of sleep deprivation. Adenosine and metabolite levels were measured by HPLC and targeted LC/MS metabolomics, respectively. Baseline adenosine and metabolite levels (12 of 16 amino acids, taurine, t4-hydroxy-proline and acetylcarnitine) were lower in hyperammonemic animals, while putrescine was higher. After sleep deprivation, hyperammonemic animals exhibited a larger increase in adenosine levels, and a number of metabolites showed a different time-course in the two groups. In both groups the recovery period was characterized by a significant decrease in wakefulness/increase in NREM and REM sleep. However, while control animals exhibited a gradual compensatory effect, hyperammonemic animals showed a significantly shorter recovery phase. In conclusion, the adenosine/metabolite/EEG response to sleep deprivation was modulated by hyperammonemia, suggesting that ammonia affects homeostatic sleep regulation and its metabolic correlates." @default.
• W2746710740 created "2017-08-31" @default.
• W2746710740 creator A5008726955 @default.
• W2746710740 creator A5018500376 @default.
• W2746710740 creator A5043258208 @default.
• W2746710740 creator A5057415923 @default.
• W2746710740 creator A5076400987 @default.
• W2746710740 creator A5078844804 @default.
• W2746710740 creator A5079044250 @default.
• W2746710740 creator A5079752095 @default.
• W2746710740 date "2017-08-31" @default.
• W2746710740 modified "2023-10-15" @default.
• W2746710740 title "Abnormalities in the Polysomnographic, Adenosine and Metabolic Response to Sleep Deprivation in an Animal Model of Hyperammonemia" @default.
• W2746710740 cites W1572338224 @default.
• W2746710740 cites W1597071043 @default.
• W2746710740 cites W1974768740 @default.
• W2746710740 cites W1975298491 @default.
• W2746710740 cites W1993063394 @default.
• W2746710740 cites W1997865837 @default.
• W2746710740 cites W2000693195 @default.
• W2746710740 cites W2006643119 @default.
• W2746710740 cites W2006701521 @default.
• W2746710740 cites W2009733684 @default.
• W2746710740 cites W2010152657 @default.
• W2746710740 cites W2014450533 @default.
• W2746710740 cites W2017767058 @default.
• W2746710740 cites W2027141772 @default.
• W2746710740 cites W2043305007 @default.
• W2746710740 cites W2045815714 @default.
• W2746710740 cites W2047556028 @default.
• W2746710740 cites W2050308647 @default.
• W2746710740 cites W2052480331 @default.
• W2746710740 cites W2053651413 @default.
• W2746710740 cites W2056409947 @default.
• W2746710740 cites W2065428236 @default.
• W2746710740 cites W2066239251 @default.
• W2746710740 cites W2067454319 @default.
• W2746710740 cites W2073744103 @default.
• W2746710740 cites W2074205443 @default.
• W2746710740 cites W2082713145 @default.
• W2746710740 cites W2084630199 @default.
• W2746710740 cites W2094712133 @default.
• W2746710740 cites W2097533515 @default.
• W2746710740 cites W2097605564 @default.
• W2746710740 cites W2105932465 @default.
• W2746710740 cites W2115343537 @default.
• W2746710740 cites W2120144854 @default.
• W2746710740 cites W2167481594 @default.
• W2746710740 cites W2482660660 @default.
• W2746710740 cites W2590107639 @default.
• W2746710740 cites W4246305685 @default.
• W2746710740 cites W8330505 @default.
• W2746710740 doi "https://doi.org/10.3389/fphys.2017.00636" @default.
• W2746710740 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5583967" @default.
• W2746710740 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28912724" @default.
• W2746710740 hasPublicationYear "2017" @default.
• W2746710740 type Work @default.
• W2746710740 sameAs 2746710740 @default.
• W2746710740 citedByCount "9" @default.
• W2746710740 countsByYear W27467107402018 @default.
• W2746710740 countsByYear W27467107402021 @default.
• W2746710740 countsByYear W27467107402022 @default.
• W2746710740 countsByYear W27467107402023 @default.
• W2746710740 crossrefType "journal-article" @default.
• W2746710740 hasAuthorship W2746710740A5008726955 @default.
• W2746710740 hasAuthorship W2746710740A5018500376 @default.
• W2746710740 hasAuthorship W2746710740A5043258208 @default.
• W2746710740 hasAuthorship W2746710740A5057415923 @default.
• W2746710740 hasAuthorship W2746710740A5076400987 @default.
• W2746710740 hasAuthorship W2746710740A5078844804 @default.
• W2746710740 hasAuthorship W2746710740A5079044250 @default.
• W2746710740 hasAuthorship W2746710740A5079752095 @default.
• W2746710740 hasBestOaLocation W27467107401 @default.
• W2746710740 hasConcept C118552586 @default.
• W2746710740 hasConcept C121446783 @default.
• W2746710740 hasConcept C126322002 @default.
• W2746710740 hasConcept C134018914 @default.
• W2746710740 hasConcept C20566671 @default.
• W2746710740 hasConcept C2776991684 @default.
• W2746710740 hasConcept C2777477808 @default.
• W2746710740 hasConcept C2778205975 @default.
• W2746710740 hasConcept C2778329153 @default.
• W2746710740 hasConcept C2781099255 @default.
• W2746710740 hasConcept C2781326671 @default.
• W2746710740 hasConcept C50156730 @default.
• W2746710740 hasConcept C513476851 @default.
• W2746710740 hasConcept C522805319 @default.
• W2746710740 hasConcept C71924100 @default.
• W2746710740 hasConceptScore W2746710740C118552586 @default.
• W2746710740 hasConceptScore W2746710740C121446783 @default.
• W2746710740 hasConceptScore W2746710740C126322002 @default.
• W2746710740 hasConceptScore W2746710740C134018914 @default.
• W2746710740 hasConceptScore W2746710740C20566671 @default.
• W2746710740 hasConceptScore W2746710740C2776991684 @default.
• W2746710740 hasConceptScore W2746710740C2777477808 @default.
• W2746710740 hasConceptScore W2746710740C2778205975 @default.
• W2746710740 hasConceptScore W2746710740C2778329153 @default.
• W2746710740 hasConceptScore W2746710740C2781099255 @default.
• W2746710740 hasConceptScore W2746710740C2781326671 @default.
• W2746710740 hasConceptScore W2746710740C50156730 @default.

• next