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- W2746801360 abstract "DNA-encoded chemical libraries have emerged as a cost-effective alternative to high-throughput screening (HTS) for hit identification in drug discovery. A key factor for productive DNA-encoded libraries is the chemical diversity of the small molecule moiety attached to an encoding DNA oligomer. The library structure diversity is often limited to DNA-compatible chemical reactions in aqueous media. Herein, we describe a facile process for reducing aryl nitro groups to aryl amines. The new protocol offers simple operation and circumvents the pyrophoric potential of the conventional method (Raney nickel). The reaction is performed in aqueous solution and does not compromise DNA structural integrity. The utility of this method is demonstrated by the versatile synthesis of benzimidazoles on DNA." @default.
- W2746801360 created "2017-08-31" @default.
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- W2746801360 date "2017-09-13" @default.
- W2746801360 modified "2023-09-30" @default.
- W2746801360 title "DNA-Compatible Nitro Reduction and Synthesis of Benzimidazoles" @default.
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- W2746801360 doi "https://doi.org/10.1021/acs.bioconjchem.7b00416" @default.
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