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• W2746815524 abstract "In the last 25 years 13C MRS has been established as the only noninvasive method for measuring glutamate neurotransmission and cell-specific neuroenergetics in humans. Although technically and experimentally challenging, 13C MRS has already provided important new information on the relationship between neuroenergetics and neuronal function, the energy cost of brain function, the high neuronal activity in the resting brain state, and how neuroenergetics and neurotransmitter cycling are altered in neurological and psychiatric disease. In this chapter the current state of 13C MRS as it is applied to study neuroenergetics and neurotransmitter cycling in health and disease in humans is reviewed. The focus is predominantly on recent findings in humans regarding metabolic pathways, applications to clinical research, and the technical status of the method. Results from in vivo 13C MRS studies in animals are discussed from the standpoint of validation of MRS measurements of neuroenergetics and neurotransmitter cycling and where they have helped identify key questions to address in human research. Controversies concerning the relation of neuroenergetics and neurotransmitter cycling and factors impacting accurate determination of fluxes through mathematical modeling are addressed. We further touch upon different 13C-labeled substrates used to study brain metabolism, before reviewing a number of human brain diseases studied using 13C MRS." @default.
• W2746815524 created "2017-08-31" @default.
• W2746815524 creator A5046602530 @default.
• W2746815524 creator A5072768373 @default.
• W2746815524 date "2014-01-01" @default.
• W2746815524 modified "2023-09-27" @default.
• W2746815524 title "Carbon (13C) MRS" @default.
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