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- W2746820070 endingPage "1138" @default.
- W2746820070 startingPage "1103" @default.
- W2746820070 abstract "c-Met is a prototype member of a subfamily of heterodimeric receptor tyrosine kinases (RTKs) and is the receptor for hepatocyte growth factor (HGF). Binding of HGF to its receptor c-Met, initiates a wide range of cellular signalling, including those involved in proliferation, motility, migration and invasion. Importantly, dysregulated HGF/c-Met signalling is a driving factor for numerous malignancies and promotes tumour growth, invasion, dissemination and/or angiogenesis. Dysregulated HGF/c-Met signalling has also been associated with poor clinical outcomes and resistance acquisition to some approved targeted therapies. Thus, c-Met kinase has emerged as a promising target for cancer drug development. Different therapeutic approaches targeting the HGF/c-Met signalling pathway are under development for targeted cancer therapy, among which small molecule inhibitors of c-Met kinase constitute the largest effort within the pharmaceutical industry. The review is an effort to summarize recent advancements in medicinal chemistry development of small molecule c-Met kinase inhibitors as potential anti-cancer agents which would certainly help future researchers to bring further developments in the discovery of small molecule c-Met kinase inhibitors." @default.
- W2746820070 created "2017-08-31" @default.
- W2746820070 creator A5016531969 @default.
- W2746820070 creator A5036313611 @default.
- W2746820070 date "2018-01-01" @default.
- W2746820070 modified "2023-10-01" @default.
- W2746820070 title "Recent advances in the discovery of small molecule c-Met Kinase inhibitors" @default.
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