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- W2746886156 abstract "Reactive sulfur species (RSS) are a family of crucial biosignals for regulating cell processes. Among these, hydrogen polysulfide (H2 Sn , n ≥ 2) is a hallmark of tumor suppressor activation and regarded as the actual regulator to mediate sulfur-related biology. However, high effective recognition of intracellular H2 Sn is insurmountable due to its extremely low concentration and the disturbance of RSS analogues. Here an H2 Sn -responsive macromolecule that can distinguish H2 Sn from intracellular RSS through polymer degradation in ultrasensitive and highly selective manner is reported. This kind of polymers can further self-assemble into vesicular nanostructure. Upon cell uptake, they can be function as all-in-one H2 Sn -nanoplatforms, in order to fulfill multiple ambitious tasks including monitoring the H2 Sn biosynthetic pathways, unraveling the puzzles of H2 Sn -mediated cellular events, and conducting H2 Sn pathological milieu-specific drug delivery." @default.
- W2746886156 created "2017-08-31" @default.
- W2746886156 creator A5012898417 @default.
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- W2746886156 date "2017-08-21" @default.
- W2746886156 modified "2023-10-01" @default.
- W2746886156 title "Hydrogen Polysulfide Biosignal-Responsive Polymersomes as a Nanoplatform for Distinguishing Intracellular Reactive Sulfur Species (RSS)" @default.
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- W2746886156 doi "https://doi.org/10.1002/smll.201701601" @default.
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