Matches in SemOpenAlex for { <https://semopenalex.org/work/W2747009072> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2747009072 abstract "Patients with Down syndrome (DS) develop neuropathological changes consistent with Alzheimer's disease (AD) by the age of 40. It is hypothesized that the increased amyloid precursor protein (APP) gene dosage due to a trisomy of chromosome 21 results in the overproduction of beta–amyloid protein (Abeta) and thereby to AD neuropathology. Previous studies suggest that increased plasma Abeta levels may antecede development of AD in general population. Our aim was to examine whether plasma Abeta levels are related to dementia in patients with DS. We prospectively selected 30 cytologically confirmed DS patients of whom 9 were demented and 21 nondemented at baseline. Neuropsychological evaluation and blood tests were done yearly during a 5–year period. Abeta levels were measured by ELISA. The APOE4 genotype was determined. Quantitative neuropathological analyses were done in 11 patients who died during the study. Plasma Abeta42 levels were substantially higher in both groups than previously reported Abeta42–levels in non–DS individuals but no significant difference between the groups was observed. The Abeta40 levels are lower than Abeta42 levels in both groups. There was no significant difference in the Abeta42/Abeta42 ratio between the groups. 6 patients became demented during the follow–up but Abeta levels did not correlate with development of dementia. APOE4 genotype did not affect Abeta levels. Moreover, the plasma Abeta levels and amyloid pathology in the brain were not correlated. Our findings showed that the APP overexpression in DS patients is reflected in blood. However, plasma Abeta does not contribute to the development of dementia and amyloid pathology in the brain in DS patients." @default.
- W2747009072 created "2017-08-31" @default.
- W2747009072 creator A5024059575 @default.
- W2747009072 creator A5028242471 @default.
- W2747009072 creator A5047079873 @default.
- W2747009072 creator A5053213129 @default.
- W2747009072 creator A5076156274 @default.
- W2747009072 creator A5081986241 @default.
- W2747009072 date "2006-07-01" @default.
- W2747009072 modified "2023-09-27" @default.
- W2747009072 title "P4-131: Relationship between dementia and plasma levels of ABETA40 and ABETA42 in patients with down syndrome - a prospective, longitudinal study" @default.
- W2747009072 doi "https://doi.org/10.1016/j.jalz.2006.05.1870" @default.
- W2747009072 hasPublicationYear "2006" @default.
- W2747009072 type Work @default.
- W2747009072 sameAs 2747009072 @default.
- W2747009072 citedByCount "0" @default.
- W2747009072 crossrefType "journal-article" @default.
- W2747009072 hasAuthorship W2747009072A5024059575 @default.
- W2747009072 hasAuthorship W2747009072A5028242471 @default.
- W2747009072 hasAuthorship W2747009072A5047079873 @default.
- W2747009072 hasAuthorship W2747009072A5053213129 @default.
- W2747009072 hasAuthorship W2747009072A5076156274 @default.
- W2747009072 hasAuthorship W2747009072A5081986241 @default.
- W2747009072 hasConcept C104317684 @default.
- W2747009072 hasConcept C118552586 @default.
- W2747009072 hasConcept C126322002 @default.
- W2747009072 hasConcept C134018914 @default.
- W2747009072 hasConcept C137555145 @default.
- W2747009072 hasConcept C142724271 @default.
- W2747009072 hasConcept C15744967 @default.
- W2747009072 hasConcept C2776156579 @default.
- W2747009072 hasConcept C2776229224 @default.
- W2747009072 hasConcept C2777633098 @default.
- W2747009072 hasConcept C2779134260 @default.
- W2747009072 hasConcept C2779483572 @default.
- W2747009072 hasConcept C2779954681 @default.
- W2747009072 hasConcept C2780130745 @default.
- W2747009072 hasConcept C2781197716 @default.
- W2747009072 hasConcept C30481170 @default.
- W2747009072 hasConcept C502032728 @default.
- W2747009072 hasConcept C54355233 @default.
- W2747009072 hasConcept C71924100 @default.
- W2747009072 hasConcept C86803240 @default.
- W2747009072 hasConceptScore W2747009072C104317684 @default.
- W2747009072 hasConceptScore W2747009072C118552586 @default.
- W2747009072 hasConceptScore W2747009072C126322002 @default.
- W2747009072 hasConceptScore W2747009072C134018914 @default.
- W2747009072 hasConceptScore W2747009072C137555145 @default.
- W2747009072 hasConceptScore W2747009072C142724271 @default.
- W2747009072 hasConceptScore W2747009072C15744967 @default.
- W2747009072 hasConceptScore W2747009072C2776156579 @default.
- W2747009072 hasConceptScore W2747009072C2776229224 @default.
- W2747009072 hasConceptScore W2747009072C2777633098 @default.
- W2747009072 hasConceptScore W2747009072C2779134260 @default.
- W2747009072 hasConceptScore W2747009072C2779483572 @default.
- W2747009072 hasConceptScore W2747009072C2779954681 @default.
- W2747009072 hasConceptScore W2747009072C2780130745 @default.
- W2747009072 hasConceptScore W2747009072C2781197716 @default.
- W2747009072 hasConceptScore W2747009072C30481170 @default.
- W2747009072 hasConceptScore W2747009072C502032728 @default.
- W2747009072 hasConceptScore W2747009072C54355233 @default.
- W2747009072 hasConceptScore W2747009072C71924100 @default.
- W2747009072 hasConceptScore W2747009072C86803240 @default.
- W2747009072 hasIssue "3S_Part_18" @default.
- W2747009072 hasLocation W27470090721 @default.
- W2747009072 hasOpenAccess W2747009072 @default.
- W2747009072 hasPrimaryLocation W27470090721 @default.
- W2747009072 hasRelatedWork W149152387 @default.
- W2747009072 hasRelatedWork W161162557 @default.
- W2747009072 hasRelatedWork W2010523347 @default.
- W2747009072 hasRelatedWork W2014284997 @default.
- W2747009072 hasRelatedWork W2027488596 @default.
- W2747009072 hasRelatedWork W2064741512 @default.
- W2747009072 hasRelatedWork W2183296633 @default.
- W2747009072 hasRelatedWork W2332807812 @default.
- W2747009072 hasRelatedWork W2748952813 @default.
- W2747009072 hasRelatedWork W97177075 @default.
- W2747009072 hasVolume "2" @default.
- W2747009072 isParatext "false" @default.
- W2747009072 isRetracted "false" @default.
- W2747009072 magId "2747009072" @default.
- W2747009072 workType "article" @default.