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• W2747128053 startingPage "1700392" @default.
• W2747128053 abstract "Changes in airway calibre have the potential to modify exhaled nitric oxide fraction (<i>F</i>_ENO) values and could hamper how <i>F</i>_ENO captures changes in asthma control. Here, our objective was to assess whether forced expiratory volume in 1 s (FEV₁) variations alter the ability of <i>F</i>_ENO to reflect asthma control. <i>F</i>_ENO, asthma control (Asthma Control Questionnaire (ACQ)) and FEV₁ were measured at least two times in 527 patients during 1819 pairs of visits. Determinants of <i>F</i>_ENO–ACQ discordance probability were evaluated through a logistic regression analysis. The effectiveness of <i>F</i>_ENO at capturing either asthma control worsening or improvement between two visits was then assessed by undertaking a stratified receiver operating characteristic curves analysis. When FEV₁ and <i>F</i>_ENO change in the same direction, the odds of <i>F</i>_ENO–ACQ being discordant are multiplied by 3 (p<0.001). The area under the curve values were 0.765 (95% CI 0.713–0.805) (improvement; p<0.001) and 0.769 (95% 0.706–0.810) (worsening; p<0.001) or 0.590 (95% 0.531–0.653) (improvement; p=0.001) and 0.498 (95% 0.416–0.567) (worsening; p=0.482) when FEV₁ and <i>F</i>_ENO changed in the opposite or same direction, respectively. The manner in which <i>F</i>_ENO and FEV₁ vary concomitantly when asthma control changes determines the ability of <i>F</i>_ENO to capture this change: parallel or opposite changes in FEV₁ and <i>F</i>_ENO either decrease or increase this ability to capture asthma control changes." @default.
• W2747128053 created "2017-08-31" @default.
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• W2747128053 date "2017-08-01" @default.
• W2747128053 modified "2023-10-01" @default.
• W2747128053 title "Airway calibre variation is a major determinant of exhaled nitric oxide's ability to capture asthma control" @default.
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• W2747128053 doi "https://doi.org/10.1183/13993003.00392-2017" @default.
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