Matches in SemOpenAlex for { <https://semopenalex.org/work/W2747207966> ?p ?o ?g. }
- W2747207966 endingPage "907" @default.
- W2747207966 startingPage "898" @default.
- W2747207966 abstract "Abstract Effective immunotherapy options for patients with non–small cell lung cancer (NSCLC) are becoming increasingly available. The immunotherapy focus has been on tumor-infiltrating T cells (TILs); however, tumor-infiltrating B cells (TIL-Bs) have also been reported to correlate with NSCLC patient survival. The function of TIL-Bs in human cancer has been understudied, with little focus on their role as antigen-presenting cells and their influence on CD4+ TILs. Compared with other immune subsets detected in freshly isolated primary tumors from NSCLC patients, we observed increased numbers of intratumoral B cells relative to B cells from tumor-adjacent tissues. Furthermore, we demonstrated that TIL-Bs can efficiently present antigen to CD4+ TILs and alter the CD4+ TIL phenotype using an in vitro antigen-presentation assay. Specifically, we identified three CD4+ TIL responses to TIL-Bs, which we categorized as activated, antigen-associated, and nonresponsive. Within the activated and antigen-associated CD4+ TIL population, activated TIL-Bs (CD19+CD20+CD69+CD27+CD21+) were associated with an effector T-cell response (IFNγ+ CD4+ TILs). Alternatively, exhausted TIL-Bs (CD19+CD20+CD69+CD27−CD21−) were associated with a regulatory T-cell phenotype (FoxP3+ CD4+ TILs). Our results demonstrate a new role for TIL-Bs in NSCLC tumors in their interplay with CD4+ TILs in the tumor microenvironment, establishing them as a potential therapeutic target in NSCLC immunotherapy. Cancer Immunol Res; 5(10); 898–907. ©2017 AACR." @default.
- W2747207966 created "2017-08-31" @default.
- W2747207966 creator A5019416691 @default.
- W2747207966 creator A5019506336 @default.
- W2747207966 creator A5030217492 @default.
- W2747207966 creator A5033336171 @default.
- W2747207966 creator A5036784999 @default.
- W2747207966 creator A5042073257 @default.
- W2747207966 creator A5044898944 @default.
- W2747207966 creator A5056661941 @default.
- W2747207966 creator A5064624622 @default.
- W2747207966 creator A5071318619 @default.
- W2747207966 creator A5079356375 @default.
- W2747207966 creator A5081007539 @default.
- W2747207966 creator A5090814068 @default.
- W2747207966 creator A5091318104 @default.
- W2747207966 date "2017-10-01" @default.
- W2747207966 modified "2023-10-10" @default.
- W2747207966 title "Antigen-Presenting Intratumoral B Cells Affect CD4+ TIL Phenotypes in Non–Small Cell Lung Cancer Patients" @default.
- W2747207966 cites W1523495124 @default.
- W2747207966 cites W1576197082 @default.
- W2747207966 cites W1605156779 @default.
- W2747207966 cites W1748415986 @default.
- W2747207966 cites W1779429182 @default.
- W2747207966 cites W1982488143 @default.
- W2747207966 cites W1987886529 @default.
- W2747207966 cites W1987962124 @default.
- W2747207966 cites W1998844140 @default.
- W2747207966 cites W2010121426 @default.
- W2747207966 cites W2019090872 @default.
- W2747207966 cites W2019182330 @default.
- W2747207966 cites W2037242921 @default.
- W2747207966 cites W2037774683 @default.
- W2747207966 cites W2041746341 @default.
- W2747207966 cites W2051236462 @default.
- W2747207966 cites W2055443961 @default.
- W2747207966 cites W2055906158 @default.
- W2747207966 cites W2057180889 @default.
- W2747207966 cites W2071793654 @default.
- W2747207966 cites W2072717004 @default.
- W2747207966 cites W2096163549 @default.
- W2747207966 cites W2099900951 @default.
- W2747207966 cites W2101335891 @default.
- W2747207966 cites W2107894271 @default.
- W2747207966 cites W2110252240 @default.
- W2747207966 cites W2115876761 @default.
- W2747207966 cites W2118425309 @default.
- W2747207966 cites W2119896120 @default.
- W2747207966 cites W2124325544 @default.
- W2747207966 cites W2134564419 @default.
- W2747207966 cites W2135322661 @default.
- W2747207966 cites W2140957786 @default.
- W2747207966 cites W2143511344 @default.
- W2747207966 cites W2156353875 @default.
- W2747207966 cites W2157860451 @default.
- W2747207966 cites W2165025975 @default.
- W2747207966 cites W2177260001 @default.
- W2747207966 cites W2186651694 @default.
- W2747207966 cites W2187668965 @default.
- W2747207966 cites W2200842302 @default.
- W2747207966 cites W2267378807 @default.
- W2747207966 cites W2346151834 @default.
- W2747207966 cites W2400586409 @default.
- W2747207966 cites W2415283090 @default.
- W2747207966 cites W2433492366 @default.
- W2747207966 cites W2469120040 @default.
- W2747207966 cites W2506653378 @default.
- W2747207966 cites W2560367415 @default.
- W2747207966 cites W2572174216 @default.
- W2747207966 cites W631045112 @default.
- W2747207966 cites W2040353461 @default.
- W2747207966 doi "https://doi.org/10.1158/2326-6066.cir-17-0075" @default.
- W2747207966 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5788174" @default.
- W2747207966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28848053" @default.
- W2747207966 hasPublicationYear "2017" @default.
- W2747207966 type Work @default.
- W2747207966 sameAs 2747207966 @default.
- W2747207966 citedByCount "163" @default.
- W2747207966 countsByYear W27472079662018 @default.
- W2747207966 countsByYear W27472079662019 @default.
- W2747207966 countsByYear W27472079662020 @default.
- W2747207966 countsByYear W27472079662021 @default.
- W2747207966 countsByYear W27472079662022 @default.
- W2747207966 countsByYear W27472079662023 @default.
- W2747207966 crossrefType "journal-article" @default.
- W2747207966 hasAuthorship W2747207966A5019416691 @default.
- W2747207966 hasAuthorship W2747207966A5019506336 @default.
- W2747207966 hasAuthorship W2747207966A5030217492 @default.
- W2747207966 hasAuthorship W2747207966A5033336171 @default.
- W2747207966 hasAuthorship W2747207966A5036784999 @default.
- W2747207966 hasAuthorship W2747207966A5042073257 @default.
- W2747207966 hasAuthorship W2747207966A5044898944 @default.
- W2747207966 hasAuthorship W2747207966A5056661941 @default.
- W2747207966 hasAuthorship W2747207966A5064624622 @default.
- W2747207966 hasAuthorship W2747207966A5071318619 @default.
- W2747207966 hasAuthorship W2747207966A5079356375 @default.
- W2747207966 hasAuthorship W2747207966A5081007539 @default.
- W2747207966 hasAuthorship W2747207966A5090814068 @default.