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- W2747217958 abstract "There is no known drug that has prevented or cured reoccurrence of epileptic seizures, hence the need to explore and compare natural remedies that are employed in folkloric treatment of convulsion. The aim of the present was to assess comparatively, the anticonvulsant activity of methanol extracts of Crinum jagus and Solanum indicum. The crude methanol extracts of the bulbs and fruits of C. jagus and S. indicum, respectively, obtained by 72 h maceration in methanol. The extracts were evaluated for anticonvulsant activity using mice and electroconvulsive shock equipment (Ugobasile ECT UNIT 7801). Four groups of six animals each were used for each extract. Group I received no extract serving as control in both cases. Groups II, III and IV received varying concentrations (32.50, 25.50; 41.50, 51.50; and 64.50, 112.50 mg/kg) for C. jagus and S. indicum respectively. All medicaments were protective against electrically induced convulsion. C. jagus showed protection after administration of 64.50 mg/kg body weight while S. indicum was at 112.50 mg/kg body weight. The two extracts justified their use in traditional and folkloric setting with the bulb extract of C. jagus possessing greater anticonvulsant effect than the fruit extract of S. indicum." @default.
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- W2747217958 date "2017-06-25" @default.
- W2747217958 modified "2023-10-14" @default.
- W2747217958 title "Comparative Analysis of the Anticonvulsant activity of Crinum jagus and Solanum indicum in Mice" @default.
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- W2747217958 doi "https://doi.org/10.20510/ukjpb/5/i3/155988" @default.
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