Matches in SemOpenAlex for { <https://semopenalex.org/work/W2747259035> ?p ?o ?g. }
- W2747259035 abstract "OBJECTIVE Human obesity is a complex metabolic disorder disproportionately affecting people of lower socioeconomic strata, and ethnic minorities, especially African Americans and Hispanics. Although genetic predisposition and a positive energy balance are implicated in obesity, these factors alone do not account for the excess prevalence of obesity in lower socioeconomic populations. Therefore, environmental factors, including exposure to pesticides, heavy metals, and other contaminants, are agents widely suspected to have obesogenic activity, and they also are spatially correlated with lower socioeconomic status. Our study investigates the causal relationship between exposure to the heavy metal, cadmium (Cd), and obesity in a cohort of children and a zebrafish model of adipogenesis. DESIGN An extensive collection of first trimester maternal blood samples obtained as part of the Newborn Epigenetics Study (NEST) were analyzed for the presence Cd, and these results were cross analyzed with the weight-gain trajectory of the children through age five years. Next, the role of Cd as a potential obesogen was analyzed in an in vivo zebrafish model. RESULTS Our analysis indicates that the presence of Cd in maternal blood during pregnancy is associated with increased risk of juvenile obesity in the offspring, independent of other variables, including lead (Pb) and smoking status. Our results are recapitulated in a zebrafish model, in which exposure to Cd at levels approximating those observed in the NEST study is associated with increased adiposity. CONCLUSION Our findings identify Cd as potential human obesogen. Moreover, these observations are recapitulated in a zebrafish model, suggesting that the underlying mechanisms may be evolutionarily conserved, and that zebrafish may be a valuable model for uncovering pathways leading to Cd-mediated obesity in human populations." @default.
- W2747259035 created "2017-08-31" @default.
- W2747259035 creator A5020256098 @default.
- W2747259035 creator A5040650222 @default.
- W2747259035 creator A5041079920 @default.
- W2747259035 creator A5050854256 @default.
- W2747259035 creator A5065434861 @default.
- W2747259035 creator A5085071991 @default.
- W2747259035 creator A5090233781 @default.
- W2747259035 date "2017-08-18" @default.
- W2747259035 modified "2023-09-28" @default.
- W2747259035 title "Cadmium Exposure Increases the Risk of Juvenile Obesity: A Human and Zebrafish Comparative Study" @default.
- W2747259035 cites W1176239876 @default.
- W2747259035 cites W1521857631 @default.
- W2747259035 cites W1532811277 @default.
- W2747259035 cites W1535485604 @default.
- W2747259035 cites W1859890772 @default.
- W2747259035 cites W1895441710 @default.
- W2747259035 cites W1916222761 @default.
- W2747259035 cites W1965312967 @default.
- W2747259035 cites W1965375347 @default.
- W2747259035 cites W1967832563 @default.
- W2747259035 cites W1975551323 @default.
- W2747259035 cites W1978529094 @default.
- W2747259035 cites W1982406683 @default.
- W2747259035 cites W1989368426 @default.
- W2747259035 cites W1995934935 @default.
- W2747259035 cites W1997074578 @default.
- W2747259035 cites W2001986412 @default.
- W2747259035 cites W2006415645 @default.
- W2747259035 cites W2007734820 @default.
- W2747259035 cites W2013816446 @default.
- W2747259035 cites W2017196485 @default.
- W2747259035 cites W2025785495 @default.
- W2747259035 cites W2026835968 @default.
- W2747259035 cites W2034173078 @default.
- W2747259035 cites W2036273116 @default.
- W2747259035 cites W2036861771 @default.
- W2747259035 cites W2037898660 @default.
- W2747259035 cites W2038073692 @default.
- W2747259035 cites W2038076288 @default.
- W2747259035 cites W2050014967 @default.
- W2747259035 cites W2054549750 @default.
- W2747259035 cites W2054551850 @default.
- W2747259035 cites W2057322930 @default.
- W2747259035 cites W2060308997 @default.
- W2747259035 cites W2060309278 @default.
- W2747259035 cites W2060742283 @default.
- W2747259035 cites W2066528365 @default.
- W2747259035 cites W2067503706 @default.
- W2747259035 cites W2068038099 @default.
- W2747259035 cites W2070010825 @default.
- W2747259035 cites W2078797241 @default.
- W2747259035 cites W2079633658 @default.
- W2747259035 cites W2081600521 @default.
- W2747259035 cites W2081745487 @default.
- W2747259035 cites W2082645779 @default.
- W2747259035 cites W2088870649 @default.
- W2747259035 cites W2093913603 @default.
- W2747259035 cites W2095863890 @default.
- W2747259035 cites W2097644754 @default.
- W2747259035 cites W2104688007 @default.
- W2747259035 cites W2107664306 @default.
- W2747259035 cites W2107832644 @default.
- W2747259035 cites W2116749304 @default.
- W2747259035 cites W2120924847 @default.
- W2747259035 cites W2125471074 @default.
- W2747259035 cites W2129768655 @default.
- W2747259035 cites W2131133382 @default.
- W2747259035 cites W2145280832 @default.
- W2747259035 cites W2147984826 @default.
- W2747259035 cites W2148732312 @default.
- W2747259035 cites W2150494230 @default.
- W2747259035 cites W2157961551 @default.
- W2747259035 cites W2158060077 @default.
- W2747259035 cites W2158489053 @default.
- W2747259035 cites W2167151437 @default.
- W2747259035 cites W2167279371 @default.
- W2747259035 cites W2169553316 @default.
- W2747259035 cites W2169783774 @default.
- W2747259035 cites W2171528132 @default.
- W2747259035 cites W2205803035 @default.
- W2747259035 cites W2278488323 @default.
- W2747259035 cites W2311133495 @default.
- W2747259035 cites W2337640592 @default.
- W2747259035 cites W2396063474 @default.
- W2747259035 cites W2474272923 @default.
- W2747259035 cites W2507924082 @default.
- W2747259035 cites W2590351842 @default.
- W2747259035 cites W2597755761 @default.
- W2747259035 cites W2609990770 @default.
- W2747259035 cites W2620558147 @default.
- W2747259035 cites W327848079 @default.
- W2747259035 cites W4253386629 @default.
- W2747259035 doi "https://doi.org/10.1101/172346" @default.
- W2747259035 hasPublicationYear "2017" @default.
- W2747259035 type Work @default.
- W2747259035 sameAs 2747259035 @default.
- W2747259035 citedByCount "0" @default.
- W2747259035 crossrefType "posted-content" @default.