Matches in SemOpenAlex for { <https://semopenalex.org/work/W2747338510> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W2747338510 abstract "Abstract : Making a major impact on the incidence and lethality of breast cancer will require a detailed understanding of the earliest tissue changes that ultimately drive the process of breast cancer development. There is no substitute for the ability to define and understand the early, pre-malignant changes as they occur in women who are breast cancer predisposed. One group of women at high breast cancer risk (up to 80 lifetime breast cancer risk) are those who have inherited mutations in the BRCA1 and BRCA2 genes. Currently, the only way these women can eliminate their risk is to undergo bilateral mastectomy before developing cancer. We have established an IRB-approved protocol that allows us to collect and analyze a portion of this tissue. Here, we propose detailed functional and molecular analysis of these tissues in order to reveal critical early steps in breast cancer development. We will then test how reversing these changes can prevent breast cancer in well-established animal models. These studies are likely to lead directly to clinical trials of new approaches to prevent breast cancer." @default.
- W2747338510 created "2017-08-31" @default.
- W2747338510 creator A5052735318 @default.
- W2747338510 date "2016-03-01" @default.
- W2747338510 modified "2023-09-23" @default.
- W2747338510 title "Defining High-Risk Precursor Signaling to Advance Breast Cancer Risk Assessment and Prevention" @default.
- W2747338510 hasPublicationYear "2016" @default.
- W2747338510 type Work @default.
- W2747338510 sameAs 2747338510 @default.
- W2747338510 citedByCount "0" @default.
- W2747338510 crossrefType "journal-article" @default.
- W2747338510 hasAuthorship W2747338510A5052735318 @default.
- W2747338510 hasConcept C121608353 @default.
- W2747338510 hasConcept C12174686 @default.
- W2747338510 hasConcept C126322002 @default.
- W2747338510 hasConcept C143998085 @default.
- W2747338510 hasConcept C2777757722 @default.
- W2747338510 hasConcept C38652104 @default.
- W2747338510 hasConcept C41008148 @default.
- W2747338510 hasConcept C530470458 @default.
- W2747338510 hasConcept C60644358 @default.
- W2747338510 hasConcept C71924100 @default.
- W2747338510 hasConcept C86803240 @default.
- W2747338510 hasConceptScore W2747338510C121608353 @default.
- W2747338510 hasConceptScore W2747338510C12174686 @default.
- W2747338510 hasConceptScore W2747338510C126322002 @default.
- W2747338510 hasConceptScore W2747338510C143998085 @default.
- W2747338510 hasConceptScore W2747338510C2777757722 @default.
- W2747338510 hasConceptScore W2747338510C38652104 @default.
- W2747338510 hasConceptScore W2747338510C41008148 @default.
- W2747338510 hasConceptScore W2747338510C530470458 @default.
- W2747338510 hasConceptScore W2747338510C60644358 @default.
- W2747338510 hasConceptScore W2747338510C71924100 @default.
- W2747338510 hasConceptScore W2747338510C86803240 @default.
- W2747338510 hasLocation W27473385101 @default.
- W2747338510 hasOpenAccess W2747338510 @default.
- W2747338510 hasPrimaryLocation W27473385101 @default.
- W2747338510 hasRelatedWork W1528181996 @default.
- W2747338510 hasRelatedWork W2045913828 @default.
- W2747338510 hasRelatedWork W2049021334 @default.
- W2747338510 hasRelatedWork W2066973526 @default.
- W2747338510 hasRelatedWork W2170856503 @default.
- W2747338510 hasRelatedWork W2194617459 @default.
- W2747338510 hasRelatedWork W2275704384 @default.
- W2747338510 hasRelatedWork W2283998212 @default.
- W2747338510 hasRelatedWork W2359219670 @default.
- W2747338510 hasRelatedWork W2579976334 @default.
- W2747338510 hasRelatedWork W2610216254 @default.
- W2747338510 hasRelatedWork W2766584719 @default.
- W2747338510 hasRelatedWork W2897847973 @default.
- W2747338510 hasRelatedWork W3010028159 @default.
- W2747338510 hasRelatedWork W3021685463 @default.
- W2747338510 hasRelatedWork W3111850949 @default.
- W2747338510 hasRelatedWork W3152714612 @default.
- W2747338510 hasRelatedWork W43001123 @default.
- W2747338510 hasRelatedWork W2023989778 @default.
- W2747338510 hasRelatedWork W2151878589 @default.
- W2747338510 isParatext "false" @default.
- W2747338510 isRetracted "false" @default.
- W2747338510 magId "2747338510" @default.
- W2747338510 workType "article" @default.