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- W2747348737 abstract "Abstract The development of many sporadic cancers is directly initiated by carcinogen exposure. Carcinogens induce malignancies by creating DNA lesions (i.e., adducts) that can result in mutations if left unrepaired. Despite this knowledge, there has been remarkably little investigation into the regulation of susceptibility to acquire DNA lesions. In this study, we present the first quantitative human genome‐wide map of DNA lesions induced by ultraviolet (UV) radiation, the ubiquitous carcinogen in sunlight that causes skin cancer. Remarkably, the pattern of carcinogen susceptibility across the genome of primary cells significantly reflects mutation frequency in malignant melanoma. Surprisingly, DNase‐accessible euchromatin is protected from UV, while lamina‐associated heterochromatin at the nuclear periphery is vulnerable. Many cancer driver genes have an intrinsic increase in carcinogen susceptibility, including the BRAF oncogene that has the highest mutation frequency in melanoma. These findings provide a genome‐wide snapshot of DNA injuries at the earliest stage of carcinogenesis. Furthermore, they identify carcinogen susceptibility as an origin of genome instability that is regulated by nuclear architecture and mirrors mutagenesis in cancer." @default.
- W2747348737 created "2017-08-31" @default.
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- W2747348737 date "2017-08-16" @default.
- W2747348737 modified "2023-10-17" @default.
- W2747348737 title "Carcinogen susceptibility is regulated by genome architecture and predicts cancer mutagenesis" @default.
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- W2747348737 doi "https://doi.org/10.15252/embj.201796717" @default.
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