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- W2747360080 abstract "Modularity is an important topological attribute for functional brain networks. Recent human fMRI studies have reported that modularity of functional networks varies not only across individuals being related to demographics and cognitive performance, but also within individuals co-occurring with fluctuations in network properties of functional connectivity, estimated over short time intervals. However, characteristics of these time-resolved functional networks during periods of high and low modularity have remained largely unexplored. In this study we investigate basic spatiotemporal properties of time-resolved networks in the high and low modularity periods during rest, with a particular focus on their spatial connectivity patterns, temporal homogeneity and test-retest reliability. We show that spatial connectivity patterns of time-resolved networks in the high and low modularity periods are represented by increased and decreased dissociation of the default mode network module from task-positive network modules, respectively. We also find that the instances of time-resolved functional connectivity sampled from within the high (respectively, low) modularity period are relatively homogeneous (respectively, heterogeneous) over time, indicating that during the low modularity period the default mode network interacts with other networks in a variable manner. We confirmed that the occurrence of the high and low modularity periods varies across individuals with moderate inter-session test-retest reliability and that it is correlated with previously-reported individual differences in the modularity of functional connectivity estimated over longer timescales. Our findings illustrate how time-resolved functional networks are spatiotemporally organized during periods of high and low modularity, allowing one to trace individual differences in long-timescale modularity to the variable occurrence of network configurations at shorter timescales." @default.
- W2747360080 created "2017-08-31" @default.
- W2747360080 creator A5002202464 @default.
- W2747360080 creator A5009949271 @default.
- W2747360080 creator A5014735844 @default.
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- W2747360080 creator A5072352855 @default.
- W2747360080 creator A5084092338 @default.
- W2747360080 creator A5087180664 @default.
- W2747360080 date "2018-10-01" @default.
- W2747360080 modified "2023-10-15" @default.
- W2747360080 title "Fluctuations between high- and low-modularity topology in time-resolved functional connectivity" @default.
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