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• W2747412048 abstract "Aging greatly increases the risk for intervertebral disc degeneration (IDD) as a result of proteoglycan loss due to reduced synthesis and enhanced degradation of the disc matrix proteoglycan (PG). How disc matrix PG homeostasis becomes perturbed with age is not known. The goal of this study is to determine whether cellular senescence is a source of this perturbation. We demonstrated that disc cellular senescence is dramatically increased in the DNA repair-deficient Ercc1-/Δ mouse model of human progeria. In these accelerated aging mice, increased disc cellular senescence is closely associated with the rapid loss of disc PG. We also directly examine PG homeostasis in oxidative damage-induced senescent human cells using an in vitro cell culture model system. Senescence of human disc cells treated with hydrogen peroxide was confirmed by growth arrest, senescence-associated β-galactosidase activity, γH2AX foci, and acquisition of senescence-associated secretory phenotype. Senescent human disc cells also exhibited perturbed matrix PG homeostasis as evidenced by their decreased capacity to synthesize new matrix PG and enhanced degradation of aggrecan, a major matrix PG. of the disc. Our in vivo and in vitro findings altogether suggest that disc cellular senescence is an important driver of PG matrix homeostatic perturbation and PG loss." @default.
• W2747412048 created "2017-08-31" @default.
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• W2747412048 date "2017-09-01" @default.
• W2747412048 modified "2023-09-28" @default.
• W2747412048 title "Senescent intervertebral disc cells exhibit perturbed matrix homeostasis phenotype" @default.
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• W2747412048 doi "https://doi.org/10.1016/j.mad.2017.08.007" @default.
• W2747412048 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5632945" @default.
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